Table 1.
Clinical information from the 28 trials used in the meta-analysis
| Study | Clinical trial phase | Trial identifier | No of patients (male); control | Age (years, mean); control | Time from STEMI to cell delivery (days) | Stem cell arm injection | Regimens dose | Myocardial function measurement |
|---|---|---|---|---|---|---|---|---|
| Lunde et al (Norway)17 | II | NCT00199823 | 50 (42); 50 (42) | 58.1; 56.7 | 6 | BM-MNCs (ii) | 6.8×107 | SPECT, echo, and MRI |
| Ge et al (People’s Republic of China)18 | UK | UK | 10 (8); 10 (10) | 58; 59 | 1 | BM-MNCs (ii) | 3.8×107 | SPECT and echo |
| Meyer et al (Germany)19 | I | NCT00224536 | 30 (20); 30 (22) | 53.4; 59.2 | 4.8 | BM-MNCs (ii) | 2.46×108 | MRI |
| Schächinger et al (Germany)20 | III | NCT00279175 | 101 (83); 103 (84) | 55; 57 | 4.3 | BM-MNCs (ii) | 2.36×108 | Echo and MRI |
| Guo (People’s Republic of China)21 | UK | UK | 11 (9); 10 (8) | 58.4; 61.6 | 1 | BM-MNCs (ii) | 3.63×107 | Echo |
| Penicka et al (Czech)22 | II | NCT00389545 | 14; 10 | 59 (mean age of the two groups of patients) | 4–11 | BM-MNCs (ii) | 2.64×108 | SPECT and echo |
| Huang et al (People’s Republic of China)23 | UK | UK | 20 (17); 20 (18) | 54.8; 55.4 | 1 | BM-MNCs (ii) | 1.2×108 | SPECT and echo |
| Huikuri et al (Finland)24 | III | NCT00363324 | 40 (36); 40 (34) | 60; 59 | 2.9 | BM-MNCs (ii) | 4.02×108 | Echo |
| Meluzín et al (Czech)25 | UK | UK | 20 (18); 20 (18) | 54; 55 | 6.8 | BM-MNCs (ii) | 1×108 | SPECT, echo, and MRI |
| Silva et al (Brazil)26 | UK | UK | 14 (7); 6 (4) | 59.7; 57.2 | 5.5 | BM-MNCs (ii) | 2.43×108 | SPECT, echo, and MRI |
| Dill et al (Germany)27 | III | NCT00279175 | 27 (24); 27 (25) | 57.9; 54.6 | 8.2 | BM-MNCs (ii) | UK | Echo and MRI |
| Herbots et al (Belgium)28 | II | NCT00264316 | 33 (27); 34 (28) | 55; 58 | 1 | BM-MNCs (ii) | 4.76×108 | Echo and MRI |
| Cao et al (People’s Republic of China)29 | UK | UK | 41 (39); 45 (42) | 50.7; 51.0 | 7 | BM-MNCs (ii) | 5×108 | SPECT and echo |
| Yao et al (People’s Republic of China)30 | UK | UK | 12 (10); 12 (11) | 52.1; 52.7 | 4.3 | BM-MNCs (ii) | 1.9×108 | SPECT, echo, and MRI |
| Grajek et al (Poland)31 | UK | UK | 31 (27); 14 (12) | 49.9; 50.9 | 4–6 | BM-MNCs (ii) | 2.34×109 | SPECT, echo, and MRI |
| Traverse et al (USA)32 | I | NCT00268307 | 30 (25); 10 (6) | 52.5; 57.5 | 4.75 | BM-MNCs (ii) | 1×108 | Echo and MRI |
| Roncalli et al (France)33 | II | NCT00200707 | 52 (42); 49 (44) | 56; 55 | 7–10 | BM-MNCs (ii) | 9.83×107 | SPECT, echo, and MRI |
| Hirsch et al (Amsterdam)34 | UK | UK | 69 (58); 65 (56) | 56; 55 | 6 | BM-MNCs (ii) | 2.96×108 | Echo and MRI |
| Sürder et al (Switzerland)35 | II | NCT00355186 | 65 (56); 67 (56) 63 (52); 67 (56) |
55; 56 62; 55 |
6 24 |
BM-MNCs (ii) | 1.59×108 1.39×108 |
MRI |
| San Roman et al (Spain)36 | II | NCT00984178 | 30 (29); 31 (28) | 54; 57 | 7.9 | BM-MNCs (ii) | 8.3×107 | SPECT, echo, and MRI |
| Hu et al (People’s Republic of China)37 | II | NCT01234181 | 11 (9); 14 (9) | 61.2; 60.6 | 6 | BM-MNCs (ii) | 1×108 | SPECT, echo, and MRI |
| Tendera et al (USA)38 | III | NCT00316381 | 80 (56); 40 (30) | 55; 59 | 7 | BM-MNCs (ii) | 1.78×108 | Echo and MRI |
| 80 (51); 40 (30) | 58; 59 | 7 | HSCs (ii) | 1.9×106 | ||||
| Mäki et al (Finland)39 | UK | UK | 11 (11); 8 (8) | 56; 55 | 3.2 | HSCs (ii) | 2.9×106 | SPECT, echo, and MRI |
| Bystroň et al (Czech)40 | UK | UK | 50 (39); 50 (38) | 57; 57 | UK | EPCs (ii) | UK | Echo |
| Janssens et al (Czech)41 | II | NCT00264316 | 33 (27); 34 (28) | 55.8; 57.9 | 7 | BMSCs (ii) | 3.2×107 | Echo and MRI |
| Xue (People’s Republic of China)42 | UK | UK | 6 (5); 6 (4) | 57.7; 57.5 | 12–14 | BMSCs (ii) | 1.5×108 | Echo |
| Plewka et al (Poland)43 | UK | UK | 38 (26); 18 (14) | 56; 56 | 3–11 | BMSCs (ii) | 1.44×108 | Echo |
| Gao et al (People’s Republic of China)44 | UK | UK | 21 (21); 22 (19) | 55.0; 58.6 | 17.1 | BMSCs (ii) | 3.08×106 | SPECT, echo, and MRI |
Abbreviations: BM-MNCs, bone marrow mononuclear cells; BMSCs, bone marrow-derived mesenchymal stem cells; echo, echocardiography; EPCs, endothelial progenitor cells; HSCs, hematopoietic stem cells; ii, intracoronary injection; MRI, magnetic resonance imaging; SPECT, single-photon-emission computed tomography; STEMI, ST-segment elevation myocardial infarction; UK, unknown.