Table 2.
Selected studies with more than 200 subjects on Phi (2010-2013)
| First author [Ref.] (n of pts.;% of PCa) |
Year | Phi cutoff | AUC | Sensitivity | Specificity |
|---|---|---|---|---|---|
|
Sokoll [70] (n=566; 43% PCa) |
2010 | not available | 0.79 (LR model) | 80 | 45 |
|
Jansen [68] (n=756; 50% PCa) |
2010 2 cohorts |
not available | 0.75(0.71) | 90 | 31 |
|
Liang (n=250+250; 50% PCa, matched) |
2011 | 36.45 (at 90% spec.) | 0.73 | 42 | 90 |
|
Guazzori (n=268; 40% PCa) |
2011 | 48.5 (at 90% spec.) Hybr. calibr. | 0.76 | 43 | 90 |
|
Catalona [66] (n=721;17% PCa) |
2011 | 21.3(24.1) Hybr.calibr. |
0.70 | 95(90) | 16(26) |
|
Loeb(see also[66]) (n=721;17%PCa) |
2013 | 24.3(27.9) WHO calibr. |
0.70 | 95(90) | 16(27) |
|
Lazzeri (n=222; 32% PCa) |
2012 | 28.8 Hybr. calibr. |
0.67 | 90 | 25 |
|
Stephan [67] (n=1362; 49% PCa) |
2013 | 31(24) | 0.74 | 95 (90) | 15(35) |
|
*Stephan [98] (n=246; 45% PCa) |
2013 | 27.5 | 0.68 | 90 | 21 |
|
*Ferro (n=300;36% PCa) |
2013 | 31.6 | 0.77 | 90 | 40 |
|
Ito (n=239;22 % PCa) |
2013 | 23.9(24.9) Hybr. calibr. |
0.72 | 95(90) | 28(33) |
|
Lazzeri [69] (n=646;40%PCa) |
2013 | 27.6 41.5 61.7 |
0.67 | 90 63 25 |
19 62 90 |
|
*Scattoni (n=211; 33 % PCa) |
2013 | 28.3(30.6) 24.1(35.5) |
0.70 all 0.69 1st bx 0.72 2nd bx |
90(80) 90(80) |
16-34 7-47 |
|
Ng (n=230;9 % PCa) |
2013 | 26.5 Hybr.calibr. |
0.78 | 90 | 50 |
*alsoPCA3 values available
Abbreviations: AUC: area under the (ROC) curve; bx: biopsy; Hybr. calibr.: Hybritech calibration (for PSA & fPSA); n.a.: not available; WHO calibr, calculated (not measured) as WHO calibrated