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. 2012 Jul 18;23(2):33–40.

Table 3.

Equations for GFR assesment from serum creatinine and cystatine concetration

  1. CREATININE-BASED EQUATIONS

    1. Cockcroft and Gault (8) (age, body mass, sex)

      GFR = (140 - age)*body mass/48,8*[Scre]

      Correction for women: multiple by 0,85

    2. MDRD equations; Levey (9,10)

      • 2.1 (age, urea and albumin)

        GFR = 170*[ Scre *0,0113]- 0,999*age- 0,176*[Surea*2,8]- 0,17*[Salbumin/10]0,318

        Correction for women: multiple by 0,762

      • 2.2 (age and urea)

        GFR = 270*[ Scre *0,0113]-1,007*age–0,18*[Surea *2,8]-0,169

        Correction for women: multiple by 0,762

      • 2.3 (short form – only age and sex)

        GFR = 186*[ Scre *0,0113]- 1,154*age-0,203

        Correction for women: 0,742

      • 2.4 (short form for standardized creatinine – MDRD4)

        GFR = 175*[Scre-stand*0,0113] -1,154*age-0,203

        Correction for women: 0,742

    3. CKD-EPI equation system; Levey (11) (age, sex, ethnicity and creatinine concetratrion)

      GFR = 141*[Scre/κ] α*age-0,993*X

      The constants „κ”, „α” and „X” are sex and ethinicity dependent and are explained in Insert 3

    The MDRD and CKD-EPI equations are also indexed to body surface area and the above equations are valid for body surface 1,73 m2. The topic of indexing is analysed in the text.

    In addition to the mentioned there are also other equations as of Walser (age, body mass and sex); Jeliffe (age); Nankiwell (age, body mass and height and urea). Special equations are for children (6)

  2. CYSTATIN C-BASED EQUATIONS

    1. Grubb (34) (sex and age in children)

      GFR = 84,69*[Scys]-1,68

      Correction for women: 0,948; for children under 14 years: 1,384

    2. Stevens (35)

      • 2.1 Stevens1 (without any correction)

        GFR = 76,7*[Scys]-1,19

      • 2.2 Stevens2 (age, sex, ethnicity)

        GFR = 127,7*[Scys]-1,17*age-0,13

        Correction for women: 0,91, for people with black skin: 1,06

    In addition there are also other equations for cystatin C-based assesment of GFR as of Bönenkamp (linear, without correction), Filler and Corao (logarithmic, without corections) and Zapitelli1 (without corrections). For details see (7)

  3. COMBINED EQUATIONS

    • 2.3 Stevens3 (weighted calculation from cystatin and creatinine, Correction for age a ethnicity)

      GFR = 177,6*[Scre]-0,65*[Scys]-0,57*age-0,2

      Correction for women: 0,82, for people with black skin: 1,11

    Other combined equations: Bouvet and Zapitelli2, also with corrections according to age, body mass and conditions as renal transplant and spina bifida. For details see (7)