Table 1. Prevalence of baseline HCV NS3/4A and NS5B polymorphisms.
| Codon | Reference (%) | Variants | Reference (%) | Variants | ||
|---|---|---|---|---|---|---|
| ≥1% (%) | <1% | ≥1% (%) | <1% | |||
| NS3/4A | HCV GT-1a (n = 229) | HCV GT-1b (n = 1196) | ||||
| 61 | T (93.0) | A, A/T (4.4) | - | S (85.2)a | T, S/T (7.4) | A/S/T, A/T, C, N |
| S, S/T (2.6) | A, A/S (4.5) | |||||
| P, P/S (2.4) | ||||||
| 80 | Q (80.8) | K, K/Q, K/N (17.5) | R, L/Q, I/K/L/Q | Q (96.5) | L, L/Q (2.4) | K, K/Q, L/M, R |
| 155 | R (99.1) | - | K | R (100) | - | - |
| 156 | A (100) | - | - | A (100) | - | - |
| 168 | D (100) | - | - | D (99.0) | E, D/E (1.0) | - |
| 344 | T (99.1) | - | A/T, N | T (67.3) | I, I/T (20.8) | I/V, D, D/V, D/I/N/V, A/I/T/V, A/S, I/M, I/M/T, N/S, N/T |
| V (6.9) | ||||||
| M, M/T (1.3) | ||||||
| S, S/T (1.2) | ||||||
| A, A/T (1.0) | ||||||
| NS5B | HCV GT-1a (n = 292) | HCV GT-1b (n = 1196) | ||||
| 421 | A (79.5) | V, A/V (20.2) | E/V | A (91.9) | V, A/V (8.0) | G, T |
| 495 | P (100) | - | - | P (100) | - | - |
| 496 | P (100) | - | - | P (99.5) | - | A, S, P/S |
| 499 | A (96.6) | T (2.7) | A/S, V | V (78.5) | A, A/V (14.8) T (5.5) | A/T, I, I/V, L |
Pooled data: 1241.2, 1241.7, SOUND-C1, -C2, and -C3, and HCVerso1 and 2 (all treatment arms).
aDenominator was 1195 due to one illegible sequence at NS3 codon 61.
GT, genotype; HCV, hepatitis C virus.