Table 2. Transportome hits which upregulate oxygen consumption >10%.
| Gene/ Gene ID | Induction OCR CA, % | Cell Index, % | Affymetrix expression | Name and function |
|---|---|---|---|---|
| RASA322821 | 10 | 106 | 0.57 | Ras GTPase-activating protein 3; calcium-release channel activity |
| ABCD45826 | 11 | 84 | 1.00 | May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. |
| TAP16890 | 11 | 84 | 0.71 | Antigen peptide transporter |
| TPCN2219931 | 12 | 114 | 1.00 | Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal membrane |
| TNPO13842 | 13 | 90 | 1.00 | Transponin, nuclear transport of proteins |
| SLC25A168034 | 14 | 118 | 1.00 | Graves disease autoantigen; Required for the accumulation of coenzyme A in the mitochondrial matrix |
| SLC7A823428 | 15 | 73 | 0.64 | LAT2, Large neutral amino acids transporter small subunit 2 |
| SLC2A36515 | 16 | 97 | 1.00 | GLUT3; Solute carrier family 2, facilitated glucose transporter member 3 |
| SLC25A1310165 | 17 | 114 | 1.00 | Calcium-binding mitochondrial carrier protein Aralar2; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. |
| SLC12A710723 | 22 | 127 | 1.00 | Potassium-chloride cotransporter 4 |
| ITGAV3685 | 23 | 57 | 1.00 | Integrin 5-alpha |
| SLC2A16513 | 27 | 68 | 1.00 | Glut-1, Solute carrier family 2, facilitated glucose transporter member 1 |
| NUDT953343 | 28 | 110 | 1.00 | ADP-ribose pyrophosphatase, mitochondrial |
| CUL58065 | 31 | 108 | 1.00 | Vasopressin-activated calcium-mobilizing receptor 1; p53 regulated, |
| SLC16A26567 | 41 | 99 | 0.79 | MCT8, Monocarboxylate transporter 8. Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr |
OCR: oxygen consumption rate; CA: cell number adjusted; Cell index: Changes in cell number compared to control transfected cells.