Table III.
N | Overall Survival | Progression-free Survival | |||||||
---|---|---|---|---|---|---|---|---|---|
2-yr (95% CI) | 4-yr (95% CI) | HR (95% CI) | P-value | 2-yr (95% CI) | 4-yr (95% CI) | HR (95% CI) | P-value | ||
Overall | 44 | 0.54 (0.41–0.72) | 0.42 (0.28–0.63) | - | - | 0.31 (0.19–0.5) | 0.18 (0.09–0.4) | - | - |
Gender | 0.91 | 0.46 | |||||||
Female | 13 | 0.57 (0.34–0.95) | 0.43 (0.2–0.92) | (reference) | 0.51 (0.29–0.9) | - | (reference) | ||
Male | 31 | 0.53 (0.38–0.75) | 0.42 (0.26–0.68) | 1.05 (0.43–2.57) | 0.24 (0.12–0.47) | 0.19 (0.08–0.43) | 1.35 (0.6–3.03) | ||
Age | 0.007 | 0.02 | |||||||
Less than 55 | 20 | 0.79 (0.62–1) | 0.7 (0.5–0.98) | (reference) | 0.46 (0.26–0.79) | 0.27 (0.11–0.68) | (reference) | ||
55 or older | 24 | 0.35 (0.19–0.62) | 0.21 (0.08–0.52) | 3.72 (1.43–9.65) | 0.2 (0.09–0.45) | 0.13 (0.04–0.42) | 2.46 (1.17–5.14) | ||
Prior Lines of Therapy | 0.34 | 0.44 | |||||||
3–4 lines | 12 | 0.67 (0.45–0.99) | 0.57 (0.35–0.94) | (reference) | 0.42 (0.21–0.81) | 0.25 (0.09–0.67) | (reference) | ||
5–6 lines | 16 | 0.60 (0.39–0.91) | 0.48 (0.26–0.88) | 1.17 (0.38–3.57) | 0.41 (0.22–0.76) | 0.27 (0.1–0.75) | 0.99 (0.40–2.41) | ||
> 6 lines | 16 | 0.33 (0.14–0.76) | - | 2.04 (0.70–5.95) | 0 | 0 | 1.64 (0.65–4.12) | ||
Donor | 0.68 | 0.55 | |||||||
Related | 14 | 0.56 (0.35–0.9) | 0.38 (0.18–0.78) | (reference) | 0.30 (0.12–0.73) | 0.1 (0.02–0.62) | (reference) | ||
Unrelated | 30 | 0.53 (0.37–0.76) | 0.47 (0.3–0.73) | 0.84 (0.36–1.95) | 0.32 (0.18–0.56) | 0.25 (0.12–0.52) | 0.80 (0.39–1.65) | ||
Match | 0.65 | 0.33 | |||||||
10/10 Unrelated | 18 | 0.57 (0.36–0.9) | 0.57 (0.36–0.9) | (reference) | 0.36 (0.18–0.72) | 0.36 (0.18–0.72) | (reference) | ||
9/10 Unrelated | 12 | 0.44 (0.22–0.89) | 0.29 (0.1–0.85) | 1.29 (0.43–3.89) | 0.25 (0.08–0.73) | 0.12 (0.02–0.72) | 1.60 (0.63–4.08) | ||
Extramedullary Manifestation | 0.01 | 0.003 | |||||||
Absent | 31 | 0.66 (0.51–0.86) | 0.53 (0.36–0.79) | (reference) | 0.41 (0.26–0.67) | 0.30 (0.15–0.58) | (reference) | ||
Present | 13 | 0.31 (0.14–0.7) | 0.21 (0.07–0.64) | 2.90 (1.27–6.60) | 0.08 (0.01–0.51) | 0 | 2.99 (1.45–6.18) | ||
Pre-Transplant Status | 0.03 | 0.12 | |||||||
VGPR/CR | 23 | 0.62 (0.44–0.87) | 0.62 (0.44–0.87) | (reference) | 0.4 (0.24–0.68) | 0.22 (0.09–0.53) | (reference) | ||
PR | 21 | 0.47 (0.29–0.74) | 0.19 (0.06–0.6) | 2.56 (1.1–5.97) | 0.14 (0.03–0.7) | 0.14 (0.03–0.7) | 1.66 (0.82–3.39) |