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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S140–S145. doi: 10.1097/PCC.0000000000000754

Figure 2.

Figure 2

A simplified schematic of the sites of action of selected therapies. Arrows indicate activation and (T) indicate inhibition. PGI2 = prostaglandin I2, ET-1 = endothelin-1, ETA = endothelin A receptor, ETB = endothelin B receptor, NO = nitric oxide, sGC = soluble guanylate cyclase, GTP = guanosine-5′-triphosphate, cGMP = guanosine-3′-5′cyclic monophosphate, GMP = guanosine monophosphate, AC = adenylate cyclase, cAMP = adenosine-3′-5′-monophosphate, AMP = adenosine monophosphate, PDE5 = phosphodiesterase type 5.