| CISHRNAbasal |
Basal production rate of CISH mRNA |
|
|
|
| CISHRNAdelay |
Delay parameter for CISH mRNA production |
|
|
|
| CISHRNAeqm |
CISH mRNA equilibrium concentration |
|
|
|
| CISHRNAturn |
CISH mRNA turnover rate |
|
* |
2.4 ± 0.5 |
| CISeqm |
CIS equilibrium concentration |
|
|
|
| CISinh |
Inhibition strength imposed by CIS |
|
|
|
| CISturn |
CIS turnover rate |
|
|
|
| EPORactJAK2 |
Activation rate of EPOR by pJAK2 |
|
* |
12 ± 4 |
| JAK2EPORdeactPTP |
Deactivation rate of JAK2 and EPOR by PTP |
|
|
|
| JAK2actEPO |
Activation rate of JAK2 by EPO |
|
* |
16 ± 3 |
| PTPactEPOR |
Activation rate of PTP by EPOR |
|
|
|
| PTPdeact |
Deactivation rate of PTP |
|
|
|
| SOCS3RNAbasal |
Basal production rate of SOCS3 mRNA |
|
|
|
| SOCS3RNAdelay |
Delay parameter for SOCS3 mRNA production |
* |
|
≥ 6.5 |
| SOCS3RNAeqm |
SOCS3 mRNA equilibrium concentration |
|
|
|
| SOCS3RNAturn |
SOCS3 mRNA turnover rate |
|
|
|
| SOCS3eqm |
SOCS3 equilibrium concentration |
|
|
|
| SOCS3inh |
Inhibition strength imposed by SOCS3 |
|
|
|
| SOCS3prom |
SOCS3 promoter activity |
* |
|
3.7 ± 0.5 |
| SOCS3turn |
SOCS3 protein turnover rate |
|
|
|
| STAT5actEPOR |
Activation rate of STAT5 by pEPOR |
|
|
|
| STAT5actJAK2 |
Activation rate of STAT5 by pJAK2 |
|
|
|
| STAT5exp |
Export rate of STAT5 from nucleus |
|
|
|
| STAT5imp |
Import rate of STAT5 to nucleus |
* |
|
4.9 ± 0.7 |
| [PTP]t = 0
|
Initial PTP concentration |
|
|
|
| nSTAT5deact |
Deactivation rate of npSTAT5 in nucleus |
* |
|
12 ± 4 |
