Table 4. Antifungal susceptibility of the Cryptococcus gattii molecular type VGIII isolates by serotype.

	MIC (μg/ml)
Serotype	Range	MIC50	MIC90	Geometric mean
Amphotericin B (p = 0.1153)
Serotype B	≤0.125–1	0.25	0.5	0.2980
Serotype C	≤0.125–2	0.25	0.5	0.2691
5-Flucytosine (p = 0.0397)*
Serotype B	0.5–8	2	4	2.095
Serotype C	0.5–4	2	4	1.580
Posaconazole (p < 0.0001)****
Serotype B	0.015–0.25	0.06	0.125	0.05698
Serotype C	0.03–0.25	0.125	0.125	0.09445
Voriconazole (p < 0.0001)****
Serotype B	≤0.008–1	0.03	0.06	0.03304
Serotype C	≤0.008–0.5	0.06	0.125	0.06346
Itraconazole (p = 0.0031)**
Serotype B	≤0.015–0.25	0.03	0.125	0.03830
Serotype C	≤0.015–2	0.06	0.125	0.06068
Fluconazole (p < 0.0001)****
Serotype B	1–128	4	8	3.927
Serotype C	1–128	8	32	8.239

Statistical significance * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 and **** p ≤ 0.0001