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. 2016 Aug 5;11(8):e0160608. doi: 10.1371/journal.pone.0160608

Fig 2. Male Townes sickle mice exhibit chronic hyperalgesia.

Fig 2

Male HbSS-Townes mice compared to age-matched male HbAA-Townes mice at 6 months (A-F) and 10 months (G-L). (M-R) Effect of age on hyperalgesia in Townes male sickle mice. Age in months ± SEM for male HbSS-Townes mice was 5.99 ± 0.66 (n = 6) at 6 months and 9.99 ± 0.07 (n = 6) at 10 months. Age in months ± SEM for male HbAA-Townes mice was 5.93 ± 0.55 (n = 6) at 6 months and 9.34 ± 0.37 (n = 6) at 10 months. (A, G, M) Mechanical hyperalgesia, thermal sensitivity to (B, H, N) heat and (C, I, O) cold, (D-E, J-K, P-Q) deep tissue hyperalgesia and (F, L, R) body weight are shown. Data are presented as mean ± SEM. PWF, paw withdrawal frequency; PWL, paw withdrawal latency; BW, body weight.