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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Cancer Discov. 2016 Aug;6(8):824–826. doi: 10.1158/2159-8290.CD-16-0665

Fig. 1. Genomic copy number causes false positive hits in CRISPR screens.

Fig. 1

(A) Technical features of the two CRISPR-based screens for essential genes in human cancer cell lines. “Cell per sgRNA” denotes the number of cells per sgRNA, or the representation of library maintained at each cell passage. (B) Both papers find that sgRNAs are depleted if they target highly amplified genomic regions, independent of gene expression status.