Table 4.
Factors Associated with an Adverse Outcome in Adults with Community-Acquired Meningitis According to Gender (N=619) on Bivariate Analysis.
| Characteristic | Male, n = 292 | Female, n = 327 |
|---|---|---|
| Odds Ratio (95% Confidence Interval) P-Value | Odds Ratio (95% Confidence Interval) P-Value |
|
| Age > 60 years | 0.36 (0.17–0.77) 0.010 | 0.12 (0.067–0.21) <0.001 |
| Baseline characteristics | ||
| Charlson Comorbidity Index score ≥ 1 | 0.58 (0.29–1.16) 0.125 | 0.225 (0.13–0.39) <0.001 |
| Immunosuppressed | 0.85 (0.36–1.98) 0.709 | 0.727 (0.31–1.71) 0.474 |
| Sinusitis or otitis | 0.48 (0.19–1.26) 0.147 | 0.47 (0.21–1.06) 0.082 |
| Presenting features | ||
| Abnormal neurological examinationa | 0.05 (0.02–0.17) <0.001 | 0.09 (0.05–0.19) <0.001 |
| Temperature >38.4°C | 0.19 (0.08–0.43) <0.001 | 0.51 (0.29–0.90) 0.020 |
| Laboratory Findings | ||
| Serum white blood cell count ≥ 12,000 cells/uL | 0.31 (0.15–0.60) <0.001 | 0.457 (0.26–0.81) 0.007 |
| CSF protein ≥ 100 mg/dL | 0.21 (0.09–0.48) <0.001 | 0.376 (0.21–0.68) 0.001 |
| CSF glucose <45 mg/dL | 0.36 (0.18–0.72) 0.004 | 0.460 (0.26–0.83) 0.010 |
a
Seizure, abnormal mental status (disorientation or Glasgow Coma Scale <15), cranial nerve abnormality, focal motor deficit, or aphasia.