Table IV.
Results of secondary association analyses with low frequency genetic variants in CHRN genes and antisocial drug dependence in white non-Hispanic subjects only from Sample 1.
| Gene | Num of Low Frequency Variants |
SKAT-O p-value |
C-alpha p-value |
|---|---|---|---|
| CHRNA1 | 31 | 0.85 | 0.76 |
| CHRNA2 | 45 | 0.53 | 0.34 |
| CHRNA5/CHRNA3/CHRNB4 | 68 | 0.02* | 0.13 |
| CHRNA4 | 32 | 1 | 0.89 |
| CHRNA6/CHRNB3 | 137 | 0.68 | 0.72 |
| CHRNA7 | 157 | 0.68 | 0.36 |
| CHRNA9 | 38 | 0.62 | 0.26 |
| CHRNA10 | 20 | 0.33 | 0.37 |
| CHRNB1 | 14 | 0.02* | 0.04* |
| CHRNB2 | 19 | 0.83 | 0.46 |
| CHRNE | 18 | 0.82 | 0.54 |
| CHRND/CHRNG | 29 | 0.42 | 0.33 |
*
indicates nominal significant association of uncorrected p-value.