Table V.
Results of association analyses with low frequency genetic variants in CHRN genes and antisocial drug dependence in all subjects in Sample 2.
| Gene | Num of Low Frequency Variants |
SKAT-O p-value |
C-alpha p-value |
|---|---|---|---|
| CHRNA1 | 159 | 1 | 0.78 |
| CHRNA2 | 201 | 0.85 | 0.36 |
| CHRNA5/CHRNA3/CHRNB4 | 397 | 0.69 | 0.03* |
| CHRNA4 | 198 | 0.26 | 0.21 |
| CHRNA6/CHRNB3 | 405 | 0.02* | 0.02* |
| CHRNA7 | 622 | 0.23 | 0.06 |
| CHRNA9 | 145 | 0.89 | 0.06 |
| CHRNA10 | 104 | 0.50 | 0.64 |
| CHRNB1 | 84 | 0.47 | 0.26 |
| CHRNB2 | 107 | 0.70 | 0.31 |
| CHRNE | 110 | 0.07 | 0.14 |
| CHRND/CHRNG | 150 | 0.54 | 0.39 |
*
indicates nominal significant association of uncorrected p-value.