Table 1.

The analysis of drug interaction in cell growth assay as in Fig. 2F using multiple statistical methods described in Supplementary Methods.

Models	Drug interaction Parameter			Estimated	95% Cl	Conclusion
	Syn.	Add.	Ant.
	II < 1	II = 1	II > 1
Chou and Talalay	Eribulin=1, MLN =50			0.688	(0.573, 0.825)	Synergy
	Eribulin=3, MLN =100			0.468	(0.334, 0.654)	Synergy
	Eribulin=5, MLN =100			0.669	(0.519, 0.866)	Synergy
	Eribulin=3, MLN =150			0.427	(0.269, 0.677)	Synergy
	Eribulin=5, MLN =150			0.505	(0.345, 0.738)	Synergy
Greco	α>0	α=0	α<0	0.949	(0.187, 1.711)	Synergy
Machado	0<h<1	h=0	h>1	0.613	(0.474, 0.753)	Synergy