Table 1.

Summary of genes directly or indirectly regulated by PXR and their functions in cardiometabolic disease.

Organ/Cell Type	Function	Gene	Reference
Liver	Cholesterol and Lipid Metabolism	CD36	[48, 76, 77]
		FAS	[48, 76]
		SCD-1	[48, 74, 76]
		ACC-1	[48]
		PPARγ	[48, 77]
		SREBP1a	[148]
		S14	[52]
		Lipin-1	[39]
		SLC13A5	[75]
		AKR1B10	[148]
		Insig-1	[149]
		HMGCS2	[45]
		CPT1a	[45]
		CYP7A1	[69, 70]
		DHCR24	[150]
	Lipoprotein Metabolism	ApoA-I	[78–80]
		ApoA-IV	[63]
		ABCA-1	[79, 80, 151]
		HL	[51, 80]
		SR-B1	[51, 80, 151]
	Glucose Metabolism	PEPCK1	[41, 152]
		G-6-P	[41, 44, 152]
		Glucokinase	[53, 54]
Intestine	Cholesterol and Lipid Metabolism	CD36	[50, 86, 92]
		NPC1L1	[50, 92]
		DGAT1	[50, 86]
		DGAT2	[50, 86]
		FABP2	[50]
		LipA	[86]
		LipF	[86]
		CYP27A1	[89, 90]
		ABCA1	[89]
Immune cells (T cells, B cells, and macrophages)	Inflammation and Atherosclerosis	CD36	[63, 119, 129]
		CD25	[108]
		IFN-γ	[108]
		IL-10	[108]
		TNFα	[113]
		COX2	[113]
Vasculature and vascular cells (ECs and SMCs)	Inflammation and Atherosclerosis	TNFα	[143]
		VCAM-1	[143]
		E-selectin	[143]
		NLRP3	[144]
		IL-1β	[144]
	Detoxification and Oxidative Stress Protection	CYP3A23	[142]
		GSTM1	[142]
		GSTM4	[144]
		MDR1	[144]
		MRP2	[142]