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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Feb 12;1859(9):1170–1182. doi: 10.1016/j.bbagrm.2016.02.008

Figure 7. SUMOylation of PXR Represses PXR Transactivation.

Figure 7

CV-1 cells were transfected with the (ER6)×3-Luc reporter gene together with the indicated expression vectors. Twenty-four hr post-transfection, cells were treated with either vehicle (Veh, 0.1% DMSO), rifampicin (Rif, 10 μM), trichostatin A (TSA, 0.5 μM), or both together for an additional twenty-four hours. Luciferase activity was normalized to β-galactosidase controls and data are presented as fold induction above vehicle control + SEM. Asterisks indicate statistically significant differences between relevant treatment groups (p<0.05).