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. Author manuscript; available in PMC: 2017 Aug 4.
Published in final edited form as: Cell Stem Cell. 2016 Jun 16;19(2):217–231. doi: 10.1016/j.stem.2016.05.012

Figure 1. SMAD signaling is active in differentiated cells but suppressed in basal stem cells of the airway epithelium.

Figure 1

A and B. Co-staining of p-SMAD1/5/8 (A) or p-SMAD2/3 (B) with basal stem cell marker p63, differentiation maker KRT8, ciliated cell marker FOXJ1, club cell marker SSEA1 and proliferation marker Ki67 on mouse tracheal sections. C-D. Co-staining of p-SMAD1/5/8 with KRT5 and KRT8 (C) and with p63, FOXJ1, and Ki67 (D) on human bronchial sections. E. Co-staining of p-SMAD2/3 with p63, KRT8, FOXJ1, and Ki67 on human bronchial sections. For all, scale bar, 20 µm. F and G. Quantification of the percentage of p-SMAD1/5/8+ and p-SMAD2/3+ cells of the indicated cell types in mouse trachea (F) and human bronchus (G), n=3.