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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Am J Psychiatry. 2015 Nov 10;173(2):174–183. doi: 10.1176/appi.ajp.2015.15030331

Figure 2. Effect of Dosage on Longitudinal Response Curve of SSRIs.

Figure 2

Figure 2 depicts the effects of dosage on the longitudinal response curve examining the efficacy of SSRIs compared to placebo over time. Each line represents the typical improvement in depressive symptoms experienced over time in SSRIs compared to placebo at a dosage isoquant. Dosages are expressed in imipramine equivalents. 100mg of imipramine = 120mg of sertraline = 100mg of fluvoxamine = 20mg of paroxetine or fluoxetine=33.3 mg of citalopram=16.7 mg of escitalopram. Abbreviations: SSRI= Selective-Serotonin Reuptake Inhibitor, SMD=Standardized Mean Difference between Active and Placebo