Table 2.

Investigations performed in the ICON-1 study

Investigation	Performed	Time taken
Blood tests	30 mL blood taken in cardiac catheterisation laboratory and at 1 year follow-up	As part of routine care
Invasive imaging: ▸Virtual histology intravascular ultrasound ▸Optical coherence tomography	In cardiac catheterisation laboratory	15 min
Arterial stiffness	Day 1 post-PCI	15 min
Endothelial function	Day 1 post-PCI	15 min
Carotid intima media thickening	Day 1 post-PCI	5 min
Transthoracic echocardiography	Day 1 post-PCI	10 min
Frailty assessments: ▸Fried criteria ▸Rockwood criteria	Day 1 post-PCI and at 1 year follow-up	5 min
Quality of life questionnaire: EQ-5D	Day 1 post-PCI and at 1 year follow-up	15 min
Cognitive assessment: Montreal cognitive assessment	Day 1 post-PCI and at 1 year follow-up	10 min

PCI, percutaneous coronary intervention.