Table 4.
Top 15 genes normally downregulated by HSF-1 independently of HS
| Transcript ID | Gene Name | Fold Change (log2) control vs. hsf-1(-);-HS | Description (WormBase) | |
|---|---|---|---|---|
| 1 | T22F3.11 | T22F3.11 | −5.85 | T22F3.11 encodes an ortholog of human solute carrier family 17 |
| 2 | T26F2.3 | eol-1 | −5.38 | eol-1 is required in the URX sensory neurons for inhibition of olfactory learning |
| 3 | B0348.2 | B0348.2 | −5.32 | B0348.2 encodes an ortholog of human lipopolysaccharide-induced TNF factor |
| 4 | Y47H10A.5 | Y47H10A.5 | −5.17 | Unknown function |
| 5 | D2023.7 | col-158 | −5.17 | col-158 is predicted to be a structural constituent of the cuticle |
| 6 | C08E3.6 | fbxa-163 | −4.95 | fbxa-163 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions |
| 7 | F07E5.9 | F07E5.9 | −4.90 | Unknown function |
| 8 | Y46C8AL.2 | clec-174 | −4.89 | clec-174 is predicted to have carbohydrate binding activity |
| 9 | T07H8.5 | srg-31 | −4.84 | srg-31 is involved in embryo development and is predicted to have transmembrane signaling receptor activity |
| 10 | ZK666.6 | clec-60 | −4.81 | clec-60 appears to play a role in the innate immune response to some bacterial pathogens |
| 11 | B0507.8 | B0507.8 | −4.64 | B0507.8 encodes an ortholog of human cingulin-like 1 |
| 12 | ZK355.8 | ZK355.8 | −4.60 | Unknown function |
| 13 | H16D19.1 | clec-13 | −4.50 | clec-13 is predicted to have carbohydrate binding activity |
| 14 | T08E11.1 | T08E11.1 | −4.37 | T08E11.1 encodes a protein containing an F-box motif predicted to mediate protein-protein interactions |
| 15 | F22G12.1 | F22G12.1 | −4.35 | F22G12.1 encodes an ortholog of human GRB10 interacting GYF protein 2 |
The transcript ID, gene name, and fold change in gene expression in the comparison of the control vs hsf-1(-);-HS are listed for the top 15 genes normally downregulated by HSF-1 independently of HS. Gene descriptions, as provided from WormBase, are also listed. A complete list of the significantly altered transcripts is given (see Additional file 2: Table S1)