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. 2016 Aug 5;14:237. doi: 10.1186/s12967-016-0987-5

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The metabolic profiles in liver tissue. The HFD induced hyperlipidemic rats were treated with or without BC for 4-week, liver tissues were collected, and metabolomics analysis was made by GC/MS. a PCA score plots of liver samples from BC treated group and untreated group; b scores plots of OPLS-DA between untreated group and BC treated group; c Pearson’s correlations of the quantities of the 13 metabolites determined from rat liver samples; d heat map showing the FC of 19 metabolites. Shades of green represent FC decrease while red represent FC increase; e simplified draft illustrating perturbed pathways involved; f differential metabolites between groups in the liver. Values were showed as mean peak intensities ± SEM. *P < 0.05; **P < 0.01, compared with untreated (HFD) group