Table 2.
Down-regulated genes (>3.0-fold down-regulation)
| Gene function | Description (gene symbol) | Acc. no. | AVE log2 | SD (LOG) | P value (Corr) | Fold change | SD |
|---|---|---|---|---|---|---|---|
| Metabolism | Transglutaminase 1 (Tgm1) | NM_031659 | −1.98 | 0.55 | 0.0002 | −3.93 | 1.87 |
| CARBONIC anhydrase 6 (Car6) | NM_001134841 | −2.03 | 0.76 | 0.0002 | −4.08 | 2.61 | |
| Phenazine biosynthesis-like protein domain containing 1 (Pbld1) | NM_138530 | −2.14 | 0.68 | 0.0001 | −4.41 | 2.60 | |
| Coproporphyrinogen oxidase (Cpox) | NM_001037095 | −2.32 | 0.45 | 0.0001 | −4.98 | 2.06 | |
| Prolyl 4-hydroxylase, alpha polypeptide III (P4ha3) | XM_006229769 | −2.36 | 0.38 | 0.0001 | −5.13 | 1.68 | |
| Signal transduction, regulation of transcription | cAMP responsive element binding protein 5 (Creb5) | XM_006236505 | −1.62 | 0.52 | 0.0001 | −3.07 | 1.26 |
| Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (Dyrk3) | NM_001024767 | −1.74 | 0.65 | 0.0006 | −3.35 | 1.95 | |
| Hypermethylated in cancer 1 (Hic1) | NM_001107021 | −1.83 | 0.70 | 0.0019 | −3.55 | 2.10 | |
| Rho guanine nucleotide exchange factor (GEF) 5 (Arhgef5) | XM_006224892 | −1.96 | 0.47 | 0.0001 | −3.89 | 1.45 | |
| Thyroid hormone responsive (Thrsp) | NM_012703 | −2.28 | 0.98 | 0.0020 | −4.86 | 5.18 | |
| Cellular retinoic acid binding protein 2 (Crabp2) | NM_017244 | −2.32 | 0.50 | 0.0001 | −4.98 | 2.42 | |
| A kinase (PRKA) anchor protein 3 (Akap3) | NM_001005557 | −2.68 | 0.35 | 0.0000 | −6.39 | 1.90 | |
| Uroplakin 1B (Upk1b) | NM_001024253 | −3.69 | 0.69 | 0.0001 | −12.89 | 7.94 | |
| Receptors, ion channels | Interleukin 22 receptor, alpha 2 (Il22ra2) | NM_001003404 | −1.62 | 0.93 | 0.0064 | −3.07 | 2.78 |
| Neurotrophic tyrosine kinase, receptor, type 3 (Ntrk3), transcript variant 3 | NM_019248 | −1.64 | 0.45 | 0.0005 | −3.12 | 1.18 | |
| Adrenoceptor alpha 1D (Adra1d) | NM_024483 | −1.69 | 0.37 | 0.0007 | −3.23 | 1.09 | |
| Lysophosphatidic acid receptor 1 (Lpar1) | NM_053936 | −1.83 | 0.51 | 0.0000 | −3.55 | 1.50 | |
| Prostaglandin F receptor (Ptgfr) | NM_013115 | −1.87 | 0.44 | 0.0000 | −3.65 | 1.40 | |
| Solute carrier family 4 (anion exchanger), member 1 (Slc4a1) | NM_012651 | −2.39 | 0.22 | 0.0000 | −5.23 | 0.94 | |
| Sarcolipin (Sln) | NM_001013247 | −3.00 | 1.41 | 0.0028 | −8.03 | 15.41 | |
| ATPase, H + transporting, lysosomal accessory protein 1-like (Atp6ap1 l) | NM_001191843 | −3.59 | 0.31 | 0.0000 | −12.06 | 3.25 | |
| Membrane proteins | Sarcolipin (Sln) | CK841541 | −2.51 | 1.08 | 0.0019 | −5.68 | 7.12 |
| Structural protein, cell adhesion | Collagen, type V, alpha 3 (Col5a3) | NM_021760 | −1.78 | 0.59 | 0.0001 | −3.43 | 1.46 |
| Contactin associated protein 1 (Cntnap1) | NM_032061 | −2.03 | 0.34 | 0.0000 | −4.09 | 1.11 | |
| Myosin binding protein H-like (Mybphl) | NM_001014042 | −2.82 | 1.17 | 0.0011 | −7.08 | 8.55 | |
| Myosin, light chain 7, regulatory (Myl7) | NM_001106017 | −3.37 | 1.66 | 0.0030 | −10.34 | 20.29 | |
| Mesothelin (Msln) | NM_031658 | −4.46 | 1.44 | 0.0010 | −22.03 | 31.18 | |
| Cell growth and differentiation | Ret proto-oncogene (Ret), transcript variant 1 | NM_012643 | −1.64 | 0.44 | 0.0000 | −3.11 | 1.15 |
| Endothelial cell-specific molecule 1 (Esm1) | NM_022604 | −2.28 | 0.39 | 0.0000 | −4.85 | 1.57 | |
| Neuronatin (Nnat), transcript variant 1 | NM_053601 | −2.34 | 1.34 | 0.0119 | −5.06 | 10.47 | |
| Endothelial cell-specific molecule 1 (Esm1) | NM_022604 | −2.36 | 0.40 | 0.0000 | −5.13 | 1.64 | |
| Epiphycan (Epyc) | NM_001108088 | −2.36 | 1.37 | 0.0083 | −5.14 | 7.64 | |
| Cyclin G1 (Ccng1) | NM_012923 | −3.36 | 0.21 | 0.0000 | −10.29 | 1.82 | |
| Tripartite motif-containing 16 (Trim16) | NM_001135033 | −6.33 | 0.41 | 0.0000 | −80.63 | 28.07 | |
| Immune response | Regenerating islet-derived 3 beta (Reg3b) | NM_053289 | −1.81 | 1.34 | 0.0300 | −3.52 | 5.83 |
| Inducible T-cell co-stimulator ligand (Icoslg) | XM_006223832 | −1.92 | 0.37 | 0.0000 | −3.79 | 1.16 | |
| Complement component 4A (Rodgers blood group) (C4a) | NM_031504 | −2.25 | 0.75 | 0.0002 | −4.77 | 3.07 | |
| Chemokine (C-X-C motif) ligand 13 (Cxcl13) | NM_001017496 | −2.48 | 0.78 | 0.0003 | −5.57 | 4.38 | |
| Similar to immunoglobulin superfamily, member 7 (RGD1559482), | NM_001168285 | −2.54 | 0.43 | 0.0000 | −5.83 | 2.19 | |
| CD1d1 molecule (Cd1d1) | NM_017079 | −2.64 | 0.53 | 0.0000 | −6.21 | 2.67 | |
| Chymase 1, mast cell (Cma1) | NM_013092 | −3.95 | 0.45 | 0.0000 | −15.40 | 6.26 | |
| Transport | Retinol binding protein 4, plasma (Rbp4) | NM_013162 | −2.09 | 1.20 | 0.0131 | −4.27 | 7.22 |
| Hormones | Inhibin alpha (Inha) | NM_012590 | −1.79 | 0.56 | 0.0020 | −3.45 | 1.80 |
| Others | Protein Arhgef5 (Source:UniProtKB/TrEMBL;Acc:E9PT59) | XM_006224892 | −1.62 | 0.54 | 0.0002 | −3.07 | 1.33 |
| Hypothetical protein LOC100302372 (LOC100302372) | NM_001162897 | −1.63 | 0.57 | 0.0004 | −3.10 | 1.69 | |
| (F344/Crj)rearranged mRNA for T-cell receptor gamma chain (1483 bp) | Z27087 | −1.65 | 0.71 | 0.0045 | −3.13 | 1.94 | |
| Similar to RIKEN cDNA 1700001E04 (LOC367428), mRNA (XM_346135) | XM_346135 | −1.65 | 0.25 | 0.0000 | −3.14 | 0.68 | |
| BTB (POZ) domain containing 9 (Btbd9) | XM_006256185 | −1.66 | 0.30 | 0.0000 | −3.15 | 0.73 | |
| Q99NG8_RAT (Q99NG8) T:G mismatch thymine glycosylase | −1.67 | 0.44 | 0.0001 | −3.17 | 1.24 | ||
| Hypothetical protein LOC689316 (LOC689316) | XR_086061 | −1.68 | 0.39 | 0.0000 | −3.21 | 1.02 | |
| Uroplakin 3B-like (Upk3bl) | NM_001109020 | −1.69 | 0.37 | 0.0013 | −3.22 | 1.04 | |
| NEUU_MOUSE (Q9QXK8) Neuromedin U-23 precursor (NmU-23) | −1.71 | 0.43 | 0.0000 | −3.28 | 1.10 | ||
| Ripply transcriptional repressor 2 (Ripply2) | XM_001064780 | −1.73 | 0.44 | 0.0000 | −3.31 | 1.22 | |
| Uncharacterized LOC100912446 (LOC100912446) | FQ221838 | −1.73 | 0.64 | 0.0005 | −3.33 | 1.76 | |
| Similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2) (LOC685619) | XM_002729250 | −1.75 | 0.32 | 0.0000 | −3.37 | 0.84 | |
| Erythrocyte membrane protein band 4.1-like 3 (Epb41l3) | NM_053927 | −1.77 | 0.90 | 0.0057 | −3.41 | 2.69 | |
| Uncharacterized LOC102556259 (LOC102556259) | XR_355327 | −1.77 | 0.38 | 0.0001 | −3.42 | 1.22 | |
| EF-hand domain family, member D1 (Efhd1) | NM_001109310 | −1.81 | 0.46 | 0.0000 | −3.50 | 1.45 | |
| Zinc finger and BTB domain containing 20 (Zbtb20) | XM_006248302 | −1.87 | 0.48 | 0.0000 | −3.67 | 1.69 | |
| Suppressor of glucose, autophagy associated 1 (Soga1) | XM_001067659 | −1.89 | 0.66 | 0.0001 | −3.72 | 2.23 | |
| Protein RGD1562667 | XM_221091 | −1.91 | 0.45 | 0.0000 | −3.75 | 1.49 | |
| Uncharacterized protein (Source:UniProtKB/TrEMBL;Acc:F1LSJ2) (ENSRNOT00000035259) | XM_001061015 | −1.93 | 0.61 | 0.0001 | −3.80 | 2.07 | |
| Uncharacterized LOC102546664 (LOC102546664) | XR_342060 | −1.95 | 0.18 | 0.0000 | −3.87 | 0.58 | |
| Protein Rsf1 (Source:UniProtKB/TrEMBL;Acc:D3ZGQ8) | XM_218939 | −1.95 | 1.05 | 0.0109 | −3.87 | 2.89 | |
| Nucleosome assembly protein 1-like 5 (Nap1l5) | NM_001044293 | −1.97 | 1.04 | 0.0039 | −3.92 | 3.86 | |
| Methyltransferase like 2B (Mettl2b) | NM_001108839 | −2.07 | 0.40 | 0.0000 | −4.20 | 1.36 | |
| Similar to immunoreceptor Ly49si3 (LOC690097) | XM_003753951 | −2.19 | 0.50 | 0.0001 | −4.55 | 2.20 | |
| Neuronal PAS domain protein 2 (Npas2) | NM_001108214 | −2.23 | 0.47 | 0.0000 | −4.69 | 1.73 | |
| FM089532 etnofat cDNA clone etnofatP0014D18 5′, mRNA sequence | FM089532 | −2.40 | 0.36 | 0.0001 | −5.28 | 1.54 | |
| Chordin-like 1 (Chrdl1) | NM_199502 | −2.46 | 0.27 | 0.0000 | −5.51 | 1.30 | |
| Uncharacterized LOC102557390 (LOC102557390) | XR_348511 | −2.54 | 0.48 | 0.0000 | −5.82 | 2.30 | |
| Q7TQ12_RAT (Q7TQ12) Aa1114 | −2.62 | 0.32 | 0.0000 | −6.14 | 1.69 | ||
| TL0ACA45YL24 mRNA sequence | FQ215947 | −2.65 | 0.48 | 0.0000 | −6.27 | 2.81 | |
| Aryl hydrocarbon receptor nuclear translocator-like (Arntl) | NM_024362 | −2.75 | 0.54 | 0.0000 | −6.75 | 2.85 | |
| Similar to RIKEN cDNA 1500015O10 (RGD1305645) | NM_001271051 | −2.84 | 0.88 | 0.0003 | −7.17 | 7.06 | |
| Uncharacterized LOC100911508 (LOC100911508) | XR_145872 | −2.86 | 0.30 | 0.0000 | −7.25 | 1.86 | |
| TL0ACA40YB18 mRNA sequence. | FQ216879 | −2.99 | 1.21 | 0.0012 | −7.94 | 9.21 | |
| Family with sequence similarity 216, member B (Fam216b) | XM_003751515 | −3.04 | 0.89 | 0.0002 | −8.25 | 6.41 | |
| SARCO_MOUSE (Q9CQD6) Sarcolipin, complete (TC628765) | AW918768 | −3.06 | 1.35 | 0.0020 | −8.33 | 14.57 | |
| Endogenous retrovirus mRNA | AY212271 | −3.51 | 1.47 | 0.0015 | −11.38 | 17.10 | |
| Uncharacterized LOC102552170 (LOC102552170) | XM_006224493 | −4.01 | 0.40 | 0.0000 | −16.09 | 5.74 | |
| O89816_9GAMR (O89816) Envelope glycoprotein | −4.04 | 0.99 | 0.0001 | −16.49 | 15.56 | ||
| Rat PRRHIS8 mRNA for ribosomal protein S8. (X56846) | X56846 | −4.14 | 0.73 | 0.0000 | −17.63 | 12.05 | |
| Elongator protein 3/MiaB/NifB | −4.21 | 0.37 | 0.0000 | −18.51 | 5.56 | ||
| Endogenous retrovirus mRNA | AY212271 | −4.21 | 1.48 | 0.0006 | −18.52 | 28.67 | |
| Similar to 60S ribosomal protein L19 (LOC316856) | XM_229366 | −4.46 | 0.84 | 0.0000 | −22.05 | 16.63 | |
| Uncharacterized LOC102554872 (LOC102554872) | XR_348916 | −4.86 | 0.35 | 0.0000 | −29.02 | 8.07 | |
| WDNM1 homolog (LOC360228) | NM_001003706 | −5.14 | 1.80 | 0.0013 | −35.24 | 76.86 |