TABLE 1.
MIC ranges, MICs, and geometric means obtained by the modified NCCLS M27-A2a BMD and Etest for 53 Malassezia species
| Malassezia species (no. of isolates) | Method | ITZb
|
FCZ
|
VOR
|
KET
|
POS
|
TER
|
AmB
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Range | MIC90 | GMc | Range | MIC90 | GM | Range | MIC90 | GM | Range | MIC90 | GM | Range | MIC90 | GM | Range | MIC90 | GM | Range | MIC100 | GM | ||
| M. furfur (12) | NCCLS | 0.03-0.06 | 0.06 | 0.03 | 0.5-32 | 8 | 1.89 | 0.03-16 | 1 | 0.10 | 0.03-1 | 0.25 | 0.05 | 0.03-32 | 2 | 0.05 | 0.03-0.50 | 0.12 | 0.10 | 0.12-16 | 1 | 1.41 |
| Etest | 0.03-0.12 | 0.12 | 0.04 | 0.5-64 | 16 | 3.17 | 0.03-32 | 2 | 0.15 | 0.04-2 | 0.12 | 0.09 | 0.03-32 | 1 | 0.09 | N/Ag | 0.50-64 | 1 | 2.38 | |||
| M. dermatis (2)f | NCCLS | 0.03d | 0.03 | 0.03 | 2d | 2 | 2 | 0.12d | 0.12 | 0.12 | 0.06-0.25 | 0.12 | 0.12 | 0.03-0.50 | 0.25 | 0.12 | 0.03-4 | 0.5 | 0.35 | 0.03-0.12 | 0.12 | 0.06 |
| Etest | 0.03d | 0.03 | 0.03 | 2d | 2 | 2 | 0.25-0.50 | 0.25 | 0.35 | 0.25-1.00 | 0.5 | 0.50 | 0.06-0.25 | 0.12 | 0.12 | N/A | 0.06-0.5 | 0.5 | 0.17 | |||
| M. globosa (22) | NCCLS | 0.03-0.12 | 0.12 | 0.05 | 1-32 | 4 | 2.34 | 0.03-0.12 | 0.06 | 0.04 | 0.03-0.12 | 0.06 | 0.04 | 0.03-0.06 | 0.06 | 0.03 | 0.03-0.12 | 0.12 | 0.05 | 0.10-4 | 1 | 0.92 |
| Etest | 0.03-0.5 | 0.12 | 0.10 | 1-64 | 6 | 3.76 | 0.01-0.5 | 0.12 | 0.05 | 0.02-0.12 | 0.06 | 0.04 | 0.03-0.12 | 0.06 | 0.04 | N/A | 0.5-32 | 4 | 3.02 | |||
| M. obtusa (2)f | NCCLS | 0.03-0.25 | 0.12 | 0.09 | 2 | 2 | 2 | 0.03-0.06 | 0.06 | 0.04 | 0.03-0.06 | 0.06 | 0.04 | 0.03d | 0.03 | 0.03 | 0.03-0.12 | 0.12 | 0.06 | 0.03-0.06 | 0.06 | 0.04 |
| Etest | 0.03-1 | 0.12 | 0.17 | 2-4 | 2 | 2.83 | 0.03-0.06 | 0.03 | 0.04 | 0.06-0.12 | 0.12 | 0.08 | 0.06-0.12 | 0.12 | 0.08 | N/A | 0.03-0.12 | 0.06 | 0.06 | |||
| M. restricta (2)f | NCCLS | 0.03d | 0.03 | 0.03 | 0.5-1 | 1 | 0.71 | 0.03d | 0.03 | 0.03 | 0.03d | 0.03 | 0.03 | 0.03d | 0.03 | 0.03 | 0.12-1 | 0.5 | 0.35 | 4-8 | 8 | 5.66 |
| Etest | 0.03d | 0.03 | 0.03 | 1-2 | 2 | 1.41 | 0.03-0.12 | 0.12 | 0.06 | 0.12d | 0.12 | 0.12 | 0.03-0.06 | 0.06 | 0.04 | N/A | 16-32 | 32 | 22.63 | |||
| M. slooffiae (4)f | NCCLS | 0.03-0.06 | 0.06 | 0.04 | 1-4 | 2 | 2 | 0.03-0.06 | 0.03 | 0.04 | 0.03-0.06 | 0.03 | 0.04 | 0.03d | 0.03 | 0.03 | 0.12-4 | 0.5 | 0.35 | 0.50-8 | 2 | 1.41 |
| Etest | 0.03-0.05 | 0.05 | 0.03 | 2-8 | 4 | 3.36 | 0.03-0.06 | 0.03 | 0.04 | 0.03-0.12 | 0.12 | 0.06 | 0.03-0.06 | 0.03 | 0.04 | N/A | 1-32 | 4 | 3.36 | |||
| M. sympodialis (8)f | NCCLS | 0.03-0.06 | 0.06 | 0.04 | 0.5-16 | 8 | 2 | 0.03-0.06 | 0.04 | 0.03 | 0.03-0.06 | 0.03 | 0.04 | 0.03-0.06 | 0.03 | 0.04 | 0.03-0.06 | 0.06 | 0.04 | 0.06-0.5 | 0.25 | 0.13 |
| Etest | 0.03-0.25 | 0.12 | 0.07 | 1-32 | 4 | 3.67 | 0.03-0.06 | 0.03 | 0.04 | 0.03-0.12 | 0.03 | 0.04 | 0.03-0.06 | 0.03 | 0.03 | N/A | 0.25-1.50 | 1 | 0.44 | |||
| M. pachydermatis (1)f | NCCLS | 0.06e | 0.06 | 0.06 | 16e | 16 | 16 | 0.03e | 0.03 | 0.03 | 0.06e | 0.06 | 0.06 | 0.12e | 0.12 | 0.12 | 0.12e | 0.12 | 0.12 | 0.12e | 0.12 | 0.12 |
| Etest | 0.12e | 0.12 | 0.12 | 32e | 32 | 32 | 0.06e | 0.06 | 0.06 | 0.12e | 0.12 | 0.12 | 0.25e | 0.25 | 0.25 | N/A | 0.5e | 0.5 | 0.5 | |||
For the NCCLS M27-A2 BMD method, see reference 14.
ITZ, itraconazole; FCZ, fluconazole; VOR, voriconazole; KET, ketoconazole; POS, posaconazole; TER, terbinafine; AmB, amphotericin B. Values are micrograms per milliliter.
GM, geometric mean.
Only one value; MICs for both strains were identical.
No range; only one M. pachydermatis strain was indicatively tested, because growth is enhanced by lipids but is not lipid dependent.
For <10 strains tested, the MIC50 is reported.
N/A, not applicable; no Etest strips were available for terbinafine.