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. Author manuscript; available in PMC: 2016 Aug 6.
Published in final edited form as: Head Neck. 2015 Jun 16;38(2):237–246. doi: 10.1002/hed.23877

Figure 4.

Figure 4

Topical application of GLV-1h68 in silk-elastin-like protein polymer (SELP) to high-volume residual disease after surgical resection enhances tumor control as compared with GLV-1h68 in phosphate-buffered saline (PBS). (A) To mimic a clinical scenario of intraoperative application of virus after incomplete surgical resection, GLV-1h68 was applied, in SELP or PBS, topically to a partially resected tumor surface in murine flanks (n = 7 per group). Approximately 120 mm of tumor was the starting volume. (B and C) In vivo luciferase expression was quantified, with representative images shown. (D) Tumor volumes demonstrate significantly smaller volumes for GLV-1h68 in SELP as compared with GLV-1h68 in PBS (p < .05; t test; 2-tailed; day 14). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]