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. Author manuscript; available in PMC: 2016 Aug 6.
Published in final edited form as: Head Neck. 2015 Jun 16;38(2):237–246. doi: 10.1002/hed.23877

Figure 5.

Figure 5

Topical application of GLV-1h68 in silk-elastin-like protein polymer (SELP) to low volume residual disease after surgical resection enhances tumor control as compared with GLV-1h68 in phosphate-buffered saline (PBS). In this postresection model, approximately 50 mm of residual tumor is the starting volume. The efficacy of applying GLV-1h68 in microscopic gel particles is also assessed. (A and B) In vivo luciferase expression was quantified, with representative images shown. (C) Tumor volumes trended lower for GLV-1h68 in SELP particles as compared with GLV-1h68 in PBS, although the difference was not statistically significant (p = .05; t test; 2-tailed; day 13). (D) GLV-1h68 in SELP particles or gel led to a higher number of animals being rendered free of disease, as compared with GLV-1h68 in PBS. There were no significant differences between the viral groups using 2-tailed Fisher's exact tests (n = 9 per group, n = 7 in control group). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]