Table 4.
Multivariate Cox regression analysis.
| Local control | Regional control | Distant control | Progression-free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
| T-category†* | 1.82 (1.2–2.8) | 0.006 | 1.58 (0.9–2.7) | 0.10 | 1.44 (1.0–2.1) | 0.05 | 1.52 (1.2–2.0) | 0.003 | 1.33 (1.0–1.8) | 0.04 |
| N-category†* | 0.50 (0.3–0.8) | 0.01 | 0.99 (0.6–1.6) | NS | 1.10 (0.8–1.5) | NS | 0.93 (0.7–1.2) | NS | 1.12 (0.9–1.4) | NS |
| Non-keratinizing histology‡ | 0.72 (0.3–1.9) | NS | 1.25 (0.3–4.7) | NS | 0.64 (0.3–1.5) | NS | 0.67 (0.4–1.2) | 0.11 | 0.52 (0.3–0.9) | 0.03 |
| Smoking pack-years† | 0.995 (0.97–1.02) | NS | 1.010 (0.99–1.04) | NS | 0.985 (0.32–1.7) | NS | 0.989 (0.97–1.01) | NS | 1.008 (1.00–1.02) | 0.19 |
| Age at diagnosis† | 1.036 (1.00–1.07) | 0.04 | 1.024 (0.98–1.07) | NS | 1.023 (1.00–1.05) | 0.08 | 1.024 (1.00–1.04) | 0.02 | 1.034 (1.01–1.06) | 0.002 |
Abbreviations: HR: hazard ratio; CI: confidence intervals; NS: not significant (p values displayed if <0.2)
†
Analyzed as an ordinal variable.
*
American Joint Committee on Cancer 7th edition.
‡
Non-keratinizing vs any other histology (including unknown).