Table 6.
Heat map of metabolites that were determined to be significantly decreased by exposure to MVE. Color is relative to the degree of change relative to control (darker green = greater difference). Numbers indicate the fold-induction level. b-faced numbers are significantly increased by the ANOVA analysis, p<0.05.
| 0h | 18h | ||||
|---|---|---|---|---|---|
| Sub Pathway | Biochemical Name |
MVE100-0 FA-0 |
MVE300-0 FA-0 |
MVE100-18 FA-18 |
MVE300-18 FA-18 |
| Glycine, Serine and Threonine Metabolism | sarcosine (N-Methylglycine) | 0.85 | 0.81 | 0.76 | 0.54 |
| Histidine Metabolism | histidine | 0.82 | 1 | 0.99 | 0.87 |
| 3-phenylpropionate (hydrocinnamate) | 0.54 | 0.9 | 1.41 | 0.96 | |
| Tryptophan Metabolism | indoleacetate | 0.72 | 1.09 | 1.22 | 0.94 |
| indolepropionate | 0.68 | 1.22 | 1.27 | 1.07 | |
| 3-indoxyl sulfate | 0.72 | 0.78 | 1.04 | 0.9 | |
| isovalerylcarnitine | 1.02 | 1.09 | 0.96 | 0.81 | |
| Urea cycle; Arginine and Proline Metabolism |
arginine | 0.75 | 0.95 | 0.89 | 1.01 |
| Gamma-glutamyl Amino Acid |
gamma-glutamylalanine | 0.76 | 1.01 | 1.12 | 1.03 |
| Glycolysis, Gluconeogenesis, and Pyruvate Metabolism |
1,5-anhydroglucitol (1,5-AG) | 1.12 | 1.12 | 0.78 | 0.84 |
| ribose | 0.92 | 1.12 | 0.52 | 0.95 | |
| fumarate | 0.63 | 0.99 | 1.29 | 1.03 | |
| malate | 0.65 | 1.08 | 1.06 | 0.98 | |
| Leucine, Isoleucine and Valine Metabolism |
eicosapentaenoate (EPA; 20:5n3) | 0.98 | 0.92 | 0.61 | 1.12 |
| dihomo-linolenate (20:3n3 or n6) | 1.58 | 1.14 | 0.59 | 0.99 | |
| azelate (nonanedioate) | 0.63 | 0.89 | 0.87 | 0.8 | |
| valerylcarnitine | 1.82 | 1.53 | 1.05 | 0.61 | |
| scyllo-inositol | 0.95 | 1.3 | 0.56 | 0.73 | |
| 1-lignoceroylglycerophosphocholine (24:0)* | 1.62 | 0.31 | 0.11 | 0.07 | |
| 1-linoleoylglycerophosphoethanolamine* | 1 | 0.94 | 0.54 | 0.77 | |
| 1-arachidonoylglycerophosphoethanolamine* | 1.13 | 1.05 | 0.51 | 0.88 | |
| 2-arachidonoylglycerophosphoethanolamine* | 1.21 | 0.99 | 0.61 | 0.81 | |
| 1-eicosatrienoylglycerophosphoethanolamine | 1 | 1.18 | 0.51 | 0.89 | |
| 1-docosahexaenoylglycerophosphoethanolan | 1.14 | 1.04 | 0.58 | 0.82 | |
| 1-linoleoylglycerol (1-monolinolein) | 1.38 | 1.35 | 0.45 | 0.82 | |
| 2-linoleoylglycerol (2-monolinolein) | 1.18 | 1.74 | 0.49 | 0.74 | |
| 1-arachidonylglycerol | 1.42 | 1.25 | 0.59 | 0.98 | |
| Purine Metabolism, (Hypo)Xanthine/lnosine containing |
inosine | 0.94 | 0.97 | 0.56 | 0.8 |
| xanthine | 2.07 | 1.45 | 0.44 | 0.9 | |
| adenosine | 0.14 | 0.66 | 0.86 | 0.68 | |
| guanosine | 0.69 | 0.64 | 0.49 | 0.78 | |
| Benzoate Metabolism | hippurate | 0.73 | 1.1 | 0.96 | 0.95 |
| 4-hydroxyhippurate | 1.17 | 0.99 | 0.75 | 0.72 | |
| 4-methylcatechol sulfate | 0.73 | 0.87 | 1 | 0.85 | |
| 4-vinylphenol sulfate | 0.5 | 0.84 | 0.9 | 0.76 | |
| Food Component/Plant | cinnamoylglycine | 0.79 | 0.99 | 1.1 | 1.23 |
| stachydrine | 0.99 | 1.06 | 0.77 | 0.75 | |