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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Comput Neurosci. 2016 Feb 11;40(2):207–229. doi: 10.1007/s10827-016-0593-9

Fig. 11.

Fig. 11

Effect of STN DBS frequency on GPi low-frequency oscillatory activity. (A,B,C,D) Spectrograms of GPi spike times during PD and three different STN DBS stimulus frequencies (10 Hz, 45 Hz and 130 Hz). During PD, GPi neurons exhibited synchronized oscillatory activity in both the alpha and beta band. 10 Hz STN DBS slightly increased this oscillatory activity. Although 45 Hz STN DBS reduced the GPi oscillatory activity, it did not completely suppress the oscillations. 130 Hz STN DBS completely suppressed the GPi oscillations and reversed PD symptoms. (E) Effect of STN DBS frequency on model GPi neurons 7–35Hz power. Standard error bars are shown for 10 ten-second simulations for each stimulus frequency

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