Fig. 9.

Alpha and beta band oscillatory activity during PD condition in model BG neurons. (A,B) Spectrograms of STN, GPi spike times exhibit prominent oscillations in both the alpha and beta band. GPi oscillatory activity in the alpha band at 9Hz is interrupted by periods of beta frequency oscillation at 20Hz. (C) Spectrogram of STN spike times shows suppression of STN beta band oscillations following reduction of NMDA-R synaptic conductance in STN (mimicking NMDA antagonist infusion) at 1sec. NMDA antagonist did not have any effect on the STN oscillatory activity at 9Hz. (D) Log-transformed STN peak beta band power reduces following simulation of NMDA antagonist infusion at ~1sec