TABLE 2.
Interpretive agreement between results of fluconazole disk diffusion tests and standard 48-h BMDa
| Organism (no. tested) | Test methodd | % of results in each categoryb
|
% Agreementc | % errors
|
||||
|---|---|---|---|---|---|---|---|---|
| S | SDD | R | VME | ME | M | |||
| C. albicans (1,631) | Ref.-MIC | 99.8 | 0.2 | 0.0 | ||||
| Ref.-disk | 99.5 | 0.4 | 0.1 | 99.6 | 0.0 | 0.1 | 0.3 | |
| Part.-disk | 97.6 | 0.7 | 1.7 | 97.7 | 0.0 | 1.4 | 0.9 | |
| C. glabrata (403) | Ref.-MIC | 69.5 | 26.3 | 4.2 | ||||
| Ref.-disk | 93.6 | 2.2 | 4.2 | 71.7 | 0.8 | 0.5 | 27.0 | |
| Part.-disk | 71.5 | 14.4 | 14.1 | 60.6 | 0.7 | 7.4 | 31.3 | |
| C. parapsilosis (400) | Ref.-MIC | 93.3 | 6.2 | 0.5 | ||||
| Ref.-disk | 91.0 | 3.0 | 6.0 | 93.3 | 0.0 | 1.0 | 5.7 | |
| Part.-disk | 85.5 | 4.0 | 10.5 | 85.5 | 0.0 | 4.8 | 9.7 | |
| C. tropicalis (327) | Ref.-MIC | 99.1 | 0.3 | 0.6 | ||||
| Ref.-disk | 98.8 | 0.6 | 0.6 | 97.9 | 0.6 | 0.6 | 0.9 | |
| Part.-disk | 89.6 | 7.0 | 3.4 | 88.7 | 0.6 | 3.4 | 7.3 | |
| All Candida spp. (2,949) | Ref.-MIC | 91.6 | 6.7 | 1.7 | ||||
| Ref.-disk | 94.1 | 2.2 | 3.7 | 92.8 | 0.2 | 0.4 | 6.6 | |
| Part.-disk | 87.9 | 4.5 | 7.6 | 87.4 | 0.2 | 3.3 | 9.1 | |
a
Fluconazole disk diffusion testing was performed according to NCCLS method M44-A, and fluconazole BMD MIC testing was performed according to NCCLS method M27-A2.
b
Fluconazole susceptibility categories: S, susceptible, MIC of ≤8 μg/ml (≥19 mm); SDD, susceptible dose dependent, MIC of 16 to 32 μg/ml (15 to 18 mm); R, resistant, MIC of ≥64 μg/ml (≤14 mm).
c
Percent categorical agreement between disk diffusion and MIC test results.
d
Ref.-MIC, MIC testing performed by ARTEMIS reference laboratory; Ref.-disk, disk testing performed by ARTEMIS reference laboratory; Part.-disk, disk testing performed by ARTEMIS participants.