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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Prog Lipid Res. 2016 May 24;63:120–131. doi: 10.1016/j.plipres.2016.05.002

Figure 3. Fatty acylation and secretion of palmitoleoylated Wnt proteins.

Figure 3

1) The Wnt precursor enters the lumen of the ER, where the signal peptide is cleaved. 2) SCD1 catalyzes formation of palmitoleoyl-CoA from palmitoyl-CoA. 3) Porcn catalyzes attachment of palmitoleoylate to Wnt. 4) Palmitoleoylated Wnt interacts with Wntless and (5) is packaged into vesicles that transit through the Golgi and then to the plasma membrane (6), where palmitoleoylated Wnt is released. 7) In some cells, Notum releases the fatty acid from Wnt.