Table 1.
Biochemistry of protein fatty acylation
Lipid | Structure | Linkage | Modified Residue | Fatty acyl Transferase | Deacylation? |
---|---|---|---|---|---|
Octanoate 8:0 |
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Oxyester | Ser | GOAT | unknown |
Myristate 14:0 |
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Amide | Gly | NMT | Removal of Myr-Gly by IpaJ |
Myristate 14:0 |
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Amide | Lys | unknown | Sirtuins |
Palmitate 16:0 |
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Thioester | Cys | DHHCs | Thioesterases (APT1,2; ABDH17) |
Palmitate 16:0 |
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Amide | Cys | Hhat | unknown |
Palmitoleic 16:1Δ9 |
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Oxyester | Ser | Porcn | Notum |
Stearate 18:0 |
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Thioester | Cys | DHHCs? | Thioesterases? |
Arach-idonate 20:4 |
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Thioester | Cys | DHHCs? | Thioesterases? |