Table 3.
miRNA | Group (N) | Brain region (Relative fold Mean ± SEM) | |||
---|---|---|---|---|---|
Hip | TC | FC | CB | ||
miR-146a | 3M C (n=3) | 1.00 ± 0.09 | 1.00 ± 0.14 | 1.00 ± 0.05 | 1.00 ± 0.12 |
3M AD (n=4) | 0.96 ± 0.08 | 0.81 ± 0.18 | 0.87 ± 0.08 | 1.09 ± 0.15 | |
6M C (n=3) | 0.99 ± 0.03 | 0.81 ± 0.22 | 0.97 ± 0.11 | 1.43 ± 0.05 | |
6M AD (n=4) | 0.83 ± 0.04* | 0.73 ± 0.20 | 0.99 ± 0.06 | 1.79 ± 0.17 | |
12M WT (n=3) | 1.19 ± 0.01 | 0.78 ± 0.19 | 1.05 ± 0.07 | 2.77 ± 0.66 | |
12M AD (n=3) | 0.95 ± 0.10 | 0.79 ± 0.21 | 0.97 ± 0.35 | 1.80 ± 0.57 | |
miR-132 | 3M WT (n=3) | 1.00 ± 0.16 | 1.00 ± 0.04 | 1.00 ± 0.25 | 1.00 ± 0.02 |
3M AD (n=4) | 1.29 ± 0.15 | 1.01 ± 0.04 | 1.09 ± 0.13 | 1.03 ± 0.10 | |
6M WT (n=3) | 0.88 ± 0.10 | 0.81 ± 0.11 | 0.98 ± 0.09 | 1.16 ± 0.06 | |
6M AD (n=4) | 1.42 ± 0.23 | 0.78 ± 0.11 | 1.06 ± 0.06 | 1.42 ± 0.09 | |
12M WT (n=3) | 1.19 ± 0.24 | 0.87 ± 0.15 | 1.04 ± 0.01 | 1.27 ± 0.11 | |
12M AD (n=3) | 1.36 ± 0.05 | 0.90 ± 0.16 | 0.99 ± 0.16 | 0.91 ± 0.13 | |
miR-9 | 3M WT (n=3) | 1.00 ± 0.06 | 1.00 ± 0.14 | 1.00 ± 0.14 | 1.00 ± 0.02 |
3M AD (n=4) | 0.80 ± 0.10 | 1.06 ± 0.04 | 0.73 ± 0.10 | 1.08 ± 0.04 | |
6M WT (n=3) | 0.75 ± 0.14 | 0.93 ± 0.20 | 0.64 ± 0.03 | 1.80 ± 0.38 | |
6M AD (n=4) | 0.76 ± 0.08 | 0.89 ± 0.07 | 0.64 ± 0.05 | 2.27 ± 0.07 | |
12M WT (n=3) | 0.91 ± 0.034 | 1.14 ± 0.08 | 0.68 ± 0.08 | 2.18 ± 0.15 | |
12M AD (n=3) | 0.60 ± 0.07* | 1.00 ± 0.12 | 0.43 ± 0.10 | 1.62 ± 0.16 | |
miR-15a | 3M WT (n=3) | 1.00 ± 0.11 | 1.00 ± 0.06 | 1.00 ± 0.22 | 1.00 ± 0.07 |
3M AD (n=4) | 0.80 ± 0.03 | 0.98 ± 0.07 | 1.12 ± 0.12 | 1.03 ± 0.06 | |
6M WT (n=3) | 0.91 ± 0.01 | 1.16 ± 0.11 | 1.06 ± 0.04 | 1.50 ± 0.20 | |
6M AD (n=4) | 0.77 ± 0.06 | 1.02 ± 0.11 | 1.03 ± 0.04 | 1.55 ± 0.09 | |
12M WT (n=3) | 0.90 ± 0.02 | 1.22 ± 0.09 | 1.16 ± 0.02 | 1.72 ± 0.12 | |
12M AD (n=3) | 0.68 ± 0.03** | 1.01 ± 0.20 | 0.75 ± 0.12* | 1.01 ± 0.13* |
Statistical significance:
p<0.05
p<0.01 M = month; WT = wildtype mice; AD = 3xTgAD mice