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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Brain Res. 2016 May 25;1646:139–151. doi: 10.1016/j.brainres.2016.05.026

Table 3.

miR-146a, -132, -9 and -15a levels in AD mice brain

miRNA Group (N) Brain region (Relative fold Mean ± SEM)
Hip TC FC CB
miR-146a 3M C (n=3) 1.00 ± 0.09 1.00 ± 0.14 1.00 ± 0.05 1.00 ± 0.12
3M AD (n=4) 0.96 ± 0.08 0.81 ± 0.18 0.87 ± 0.08 1.09 ± 0.15
6M C (n=3) 0.99 ± 0.03 0.81 ± 0.22 0.97 ± 0.11 1.43 ± 0.05
6M AD (n=4) 0.83 ± 0.04* 0.73 ± 0.20 0.99 ± 0.06 1.79 ± 0.17
12M WT (n=3) 1.19 ± 0.01 0.78 ± 0.19 1.05 ± 0.07 2.77 ± 0.66
12M AD (n=3) 0.95 ± 0.10 0.79 ± 0.21 0.97 ± 0.35 1.80 ± 0.57
miR-132 3M WT (n=3) 1.00 ± 0.16 1.00 ± 0.04 1.00 ± 0.25 1.00 ± 0.02
3M AD (n=4) 1.29 ± 0.15 1.01 ± 0.04 1.09 ± 0.13 1.03 ± 0.10
6M WT (n=3) 0.88 ± 0.10 0.81 ± 0.11 0.98 ± 0.09 1.16 ± 0.06
6M AD (n=4) 1.42 ± 0.23 0.78 ± 0.11 1.06 ± 0.06 1.42 ± 0.09
12M WT (n=3) 1.19 ± 0.24 0.87 ± 0.15 1.04 ± 0.01 1.27 ± 0.11
12M AD (n=3) 1.36 ± 0.05 0.90 ± 0.16 0.99 ± 0.16 0.91 ± 0.13
miR-9 3M WT (n=3) 1.00 ± 0.06 1.00 ± 0.14 1.00 ± 0.14 1.00 ± 0.02
3M AD (n=4) 0.80 ± 0.10 1.06 ± 0.04 0.73 ± 0.10 1.08 ± 0.04
6M WT (n=3) 0.75 ± 0.14 0.93 ± 0.20 0.64 ± 0.03 1.80 ± 0.38
6M AD (n=4) 0.76 ± 0.08 0.89 ± 0.07 0.64 ± 0.05 2.27 ± 0.07
12M WT (n=3) 0.91 ± 0.034 1.14 ± 0.08 0.68 ± 0.08 2.18 ± 0.15
12M AD (n=3) 0.60 ± 0.07* 1.00 ± 0.12 0.43 ± 0.10 1.62 ± 0.16
miR-15a 3M WT (n=3) 1.00 ± 0.11 1.00 ± 0.06 1.00 ± 0.22 1.00 ± 0.07
3M AD (n=4) 0.80 ± 0.03 0.98 ± 0.07 1.12 ± 0.12 1.03 ± 0.06
6M WT (n=3) 0.91 ± 0.01 1.16 ± 0.11 1.06 ± 0.04 1.50 ± 0.20
6M AD (n=4) 0.77 ± 0.06 1.02 ± 0.11 1.03 ± 0.04 1.55 ± 0.09
12M WT (n=3) 0.90 ± 0.02 1.22 ± 0.09 1.16 ± 0.02 1.72 ± 0.12
12M AD (n=3) 0.68 ± 0.03** 1.01 ± 0.20 0.75 ± 0.12* 1.01 ± 0.13*

Statistical significance:

*

p<0.05

**

p<0.01 M = month; WT = wildtype mice; AD = 3xTgAD mice