Table 2. Summary of pHLA-I stability data.
| t1/2 percentile | t1/2 percentile | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Group | Allotype | Data points | 95 | 5 | Group | Allotype | Data points | 95 | 5 |
| A1 | HLA-A*01:01 | 220 | 40.3 | 0 | B7 | HLA-B*07:02 | 647 | 9.8 | 0 |
| HLA-A*29:02 | 383 | 20.4 | 0.1 | HLA-B*35:01 | 650 | 7.4 | 0 | ||
| HLA-A*30:02 | 367 | 14.1 | 0 | HLA-B*35:03 | 376 | 7 | 0.2 | ||
| HLA-A*43:01 | 359 | 6.7 | 0 | HLA-B*39:10 | 376 | 32.5 | 0 | ||
| HLA-A*80:01 | 351 | 2 | 0 | HLA-B*42:01 | 350 | 34.1 | 0.4 | ||
| HLA-B*42:02 | 376 | 13 | 0 | ||||||
| A2 | HLA-A*02:01 | 1023 | 28.7 | 0.1 | HLA-B*51:01 | 353 | 15 | 0 | |
| HLA-A*02:03 | 379 | 46.7 | 0.3 | HLA-B*54:01 | 357 | 10.8 | 0 | ||
| HLA-A*02:10 | 370 | 31.3 | 0.1 | HLA-B*55:01 | 378 | 9.7 | 0 | ||
| HLA-A*02:11 | 379 | 28.9 | 0.8 | HLA-B*56:01 | 368 | 7.8 | 0 | ||
| HLA-A*02:12 | 372 | 37.4 | 0.4 | HLA-B*81:01 | 367 | 2.7 | 0 | ||
| HLA-A*02:16 | 373 | 36.5 | 0.4 | ||||||
| HLA-A*02:19 | 354 | 39.6 | 0.2 | B8 | HLA-B*08:01 | 465 | 1.2 | 0 | |
| HLA-A*02:50 | 375 | 23.2 | 0.7 | HLA-B*08:03 | 350 | 1.9 | 0 | ||
| HLA-B*14:01 (C67S) | 374 | 0.6 | 0 | ||||||
| A3 | HLA-A*03:01 | 861 | 52.2 | 0 | HLA-B*14:02 (C67S) | 382 | 4.5 | 0 | |
| HLA-A*11:01 | 577 | 71.7 | 0.1 | ||||||
| HLA-A*30:01 | 386 | 37.4 | 0 | B27 | HLA-B*27:02 | 359 | 34.9 | 0 | |
| HLA-A*31:01 | 382 | 77.3 | 0 | HLA-B*27:03 | 368 | 25.1 | 0 | ||
| HLA-A*33:03 | 371 | 56 | 0 | HLA-B*27:05 | 366 | 25.3 | 0 | ||
| HLA-A*68:01 | 387 | 56 | 0 | HLA-B*27:20 | 368 | 8.3 | 0 | ||
| HLA-A*74:01 | 361 | 94.5 | 0 | ||||||
| B39 | HLA-B*15:10 | 363 | 7.7 | 0 | |||||
| A24 | HLA-A*23:01 | 372 | 37.3 | 0.4 | HLA-B*39:01 | 680 | 9.3 | 0 | |
| HLA-A*24:02 | 573 | 30.2 | 0.2 | HLA-B*39:02 | 375 | 14.9 | 0 | ||
| HLA-A*24:03 | 512 | 37.6 | 0.2 | HLA-B*39:06 (C67S) | 379 | 0.5 | 0 | ||
| HLA-A*24:07 | 352 | 24.4 | 0.2 | ||||||
| HLA-A*24:19 | 378 | 2.7 | 0 | B44 | HLA-B*18:01 | 359 | 8 | 0 | |
| HLA-A*32:07 | 364 | 43.5 | 0 | HLA-B*40:01 | 302 | 2.3 | 0 | ||
| HLA-B*41:01 | 368 | 3.5 | 0 | ||||||
| A26 | HLA-A*25:01 | 363 | 21.7 | 0 | HLA-B*44:05 | 352 | 12.1 | 0 | |
| HLA-A*26:01 | 272 | 23.8 | 0 | HLA-B*45:01 | 368 | 5.33 | 0 | ||
| HLA-A*26:02 | 343 | 35.6 | 0 | ||||||
| HLA-A*26:03 | 341 | 15.3 | 0 | B58 | HLA-B*15:17 | 362 | 6.3 | 0 | |
| HLA-A*66:01 | 382 | 3.6 | 0 | HLA-B*57:01 | 349 | 12.4 | 0 | ||
| HLA-A*68:23 | 369 | 9.9 | 0 | HLA-B*57:02 | 363 | 7.2 | 0 | ||
| HLA-B*57:03 | 369 | 7.8 | 0.6 | ||||||
| Others | HLA-A*02:05 | 21 | 26.3 | 0.6 | HLA-B*58:01 | 379 | 21.3 | 0 | |
| HLA-A*32:01 | 32 | 57.2 | 0 | ||||||
| HLA-A*68:02 | 16 | 15.8 | 0.1 | B62 | HLA-B*15:01 | 1070 | 12.5 | 0 | |
| HLA-A*69:01 | 15 | 4.1 | 0 | HLA-B*15:02 | 349 | 5.7 | 0 | ||
| HLA-B*13:02 | 7 | 6 | 0 | HLA-B*46:01 | 361 | 5.3 | 0 | ||
| HLA-B*35:08 | 27 | 8.7 | 0 | ||||||
| HLA-B*40:02 | 19 | 24.4 | 0.5 | ||||||
75 HLA-I allotypes were grouped into 12 “supertype” group by predicted binding motif and screened for pMHC-I complex stability to peptide sets representing each “supertype” binding preference. The extra group “Others” contain molecules with few binding data obtained from an in-house database. For each molecule is indicated the total number of peptide binding measurements, and 95% and 5% percentile half-life values. The 95 percentile value corresponds to the half-time of the top 5% most stable peptide and 5 percentile value to the bottom 5% least stable peptide for each HLA molecule.