Table 1.
Demographic and Clinical Characteristics of Randomized Subjects
| Total (n=14) | Placebo (n=7) | Mirtazapine (n=7) | χ 2 | sig | ||||
|---|---|---|---|---|---|---|---|---|
| Sex (% female) | 28.6% | 14.3% | 42.9% | 1.40 | 0.6 | |||
| Ethnic (% white) | 50.0% | 71.4% | 28.6% | 2.57 | 0.3 | |||
| Baseline | Mean | S.D. | Mean | S.D. | Mean | S.D. | t | sig |
| BDI Total | 26.9 | 9.6 | 26.1 | 11.7 | 27.6 | 7.7 | −0.27 | 0.8 |
| OCDS Total | 24.2 | 7.4 | 24.3 | 7.8 | 24.1 | 7.7 | 0.04 | 1.0 |
| Drinks per Week | 33.6 | 13.6 | 37.1 | 14.5 | 30.0 | 12.6 | 0.98 | 0.3 |
| Drinks per drinking day | 6.6 | 2.0 | 6.9 | 1.7 | 6.4 | 2.4 | 0.47 | 0.4 |
| Days of Alcohol Use per Week | 5.2 | 1.9 | 5.4 | 2.0 | 5.0 | 2.0 | 0.40 | 0.7 |
| Heavy Drinking Days / Week | 3.5 | 1.6 | 3.9 | 1.2 | 3.1 | 1.9 | 0.85 | 0.4 |
| Week 12 | ||||||||
| BDI Total | 9.5 | 6.6 | 10.1 | 8.7 | 8.9 | 4.4 | 0.35 | 0.7 |
| OCDS Total | 12.9 | 5.6 | 11.6 | 6.7 | 14.1 | 4.4 | −0.85 | 0.4 |
| Drinks per Week | 24.9 | 16.8 | 24.0 | 16.3 | 25.7 | 18.7 | −0.18 | 0.9 |
| Drinks per drinking day | 3.9 | 1.5 | 4.4 | 1.5 | 3.5 | 1.6 | 1.06 | 0.3 |
| Days of Alcohol Use per Week | 6.4 | 5.4 | 6.4 | 6.0 | 6.4 | 5.1 | 0.00 | 1.0 |
| Heavy Drinking Days / Week | 1.6 | 1.2 | 1.4 | 1.3 | 1.9 | 1.1 | −0.68 | 0.5 |
| Change from Baseline to Week 12 | ||||||||
| Δ BDI Total | −17.4 | 8.5 | −16.0 | 11.0 | −18.7 | 5.7 | 0.58 | 0.6 |
| Δ OCDS Total | −11.4 | 7.0 | −12.7 | 7.4 | −10.0 | 6.9 | −0.71 | 0.5 |
| Δ Drinks per Week | −8.7 | 20.4 | −13.1 | 19.6 | −4.3 | 21.8 | −0.80 | 0.4 |
| Δ Drinks per drinking day | −2.7 | 2.8 | −2.5 | 2.0 | −2.9 | 3.7 | 0.20 | 0.8 |
| Δ Days of Alcohol Use / Week | +1.2 | 4.5 | +1.0 | 5.1 | +1.4 | 4.2 | −0.17 | 0.9 |
| Δ Heavy Drinking Days / Week | −1.9 | 1.7 | −2.4 | 1.3 | −1.3 | 2.0 | −1.29 | 0.2 |
Note: BDI=Beck Depression Inventory, OCDS= Obsessive Compulsive Drinking Scale, S.D.=Standard Deviation, sig=statistical significance