TABLE 4.
MIC profiles for transformants and associated strains
| S. pneumoniae isolate | MIC (μg/ml)a
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ERY | CLR | CLI | CETH | TEL | CIP | TET | PEN | SGRA | SGRB | |
| CP1250 | 0.03 | 0.015 | 0.015 | 0.002 | 0.004 | 1 | 0.25 | 0.125 | 4 | 1 |
| CP1250 + msr(D) | 2 | 2 | 0.03 | 0.004 | 0.06 | 2 | 0.5 | 0.125 | 4 | 1 |
| CP1250 + mef(E) | 4 | 4 | 0.125 | 0.002 | 0.004 | 1 | 0.25 | 0.125 | NDb | ND |
| CP1250 + mef(A) | 8 | 4 | 0.125 | 0.002 | 0.004 | 1 | 0.25 | 0.125 | ND | ND |
| Clinical isolate 5645 [mef(E) and msr(D) donor DNA] | 4 | 4 | 0.03 | 0.004 | 0.06 | 2 | 1 | 8 | 16 | 2 |
| Clinical isolate 2511 [mef(A) donor DNA] | 8 | 8 | 0.06 | 0.008 | 0.06 | 0.5 | 0.5 | 0.125 | 16 | 2 |
| ATCC 49619 | 0.015 | 0.03 | 0.03 | 0.0005 | 0.004 | 1 | 0.5 | 2 | 8 | 1 |
a
ERY, erythromycin; CLR, clarithromycin; CLI, clindamycin; CETH, cethromycin; TEL, telithromycin; CIP, ciprofloxacin; TET, tetracycline; PEN, penicillin; SGRA, streptogramin A; SGRB, streptogramin B.
b
ND, not done.