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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: J Immunol. 2016 Jul 11;197(4):1118–1126. doi: 10.4049/jimmunol.1600549

Figure 2. Greater innate cytokines produced by stimulated PBMCs from SSTI patients than controls.

Figure 2

A. PBMCs from uninfected controls (Ctrl) and SSTI infected patients (Pt) were stimulated with Pam3CysK4 (Pam3, top panels) or with USA300 MRSA sonicates (bottom panels) for 24 hours. Supernatants were assayed for IL-1β, IL-6 and TNF by ELISA. Statistical significance between uninfected and infected D0 was calculated using the Chi-square test and between D0 and D40 using the McNemar test for paired data. B. Levels of cytokines induced by USA300 MRSA sonicates were compared between PBMCs from patients with documented non-USA300 infection and PBMCs from patients with documented USA300 infection. Plots represent Mean + SEM. Statistical significance was calculated using the Mann-Whitney test. * p<0.05, ** p<0.01, ***p<0.001.