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(A) Nucleofection of human B-cells with mutant IRF2BP2 construct (p.S551N) leads to reduced plasmablast formation 7 days after CPG stimulation versus wild type IRF2BP2 nucleofection, which reached statistical significance (p<0.02, denoted by *). Data shown reflects mean percentage of plasmablast formation after 7 days of culture, and represents five duplicate runs. (B) On the SVM hyperplane, the proband was predicted to fall in the non-polygenic region.
