Table 3. Support Vector Algorithm predictions for monogenic CVID-like immunodeficiency disorders.
Of 9 additional subjects evaluated, all were uniformly grouped as different from polygenic CVID by the SVM algorithm.
| Subject # | Immune disorder | Mutation | CVID algorithm prediction |
|---|---|---|---|
| 1 | CD27 deficiency | p.Trp8X | Non-polygenic |
| 2 | LRBA | p.Arg1683X | Non-polygenic |
| 3 | LRBA | p.Iso2657Ser | Non-polygenic |
| 4 | BAFFR | c.189-96del | Non-polygenic |
| 5 | ICOS | c.126-568 del | Non-polygenic |
| 6 | CD21 | c.1225+1G>C | Non-polygenic |
| 7 | TACI mutation | p.Cys104Arg (heterozygous) | Non-polygenic |
| 8 | TACI mutation | p.Cys104Arg (heterozygous) | Non-polygenic |
| 9 | TACI mutation | p.Cys104Arg (heterozygous) | Non-polygenic |