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. Author manuscript; available in PMC: 2017 Aug 3.
Published in final edited form as: Neuron. 2016 Jul 7;91(3):587–601. doi: 10.1016/j.neuron.2016.06.016

Figure 5. Effect of serotonin and dopamine agonists on ASR habituation and spontaneous swim behavior.

Figure 5

(A–C) Treatment with serotonin receptor agonist (quipazine 50 µM). (A) Quipazine treatment does not significantly affect ASR probability under non-habituating conditions (nControl = 420, nQuipazine = 420, z = 1.53, P > 0.1). (B) Quipazine treatment shifts the habituation index (HI) frequency distribution to lower values (less habituation) (nControl = 261, nQuipazine = 281, z = 8.4, P < 10−16). (C) Quipazine treatment shifts the frequency distribution of total displacement during 10 minutes to lower values when compared to control group (nControl = 359, nQuipazine = 394, z = 2.5 P < 0.015). (D–F) Treatment with dopamine receptor agonist (apomorphine 15 µM). (D) Apomorphine treatment increases initial ASR probability (nControl = 420, nApomorphine = 420, z = 8.2, P < 10−15). (E) Apomorphine treatment shifts HI frequency distribution to higher values (greater habituation) (nControl = 261, nApomorphine = 358, z = 7.38, P < 10−12). (F) Apomorphine treatment significantly shifts the frequency distribution of total displacement values during 10 minutes to lower values when compared to control group (nControl = 359, napomorphine = 383, z = 15.12, P < 10−50).