Table 1.

Array heritabilities ( $h_{\mathrm{g}}^2$) and standard errors (s.e.) for invasive EOC according to histological subtype

Subtype	Cases	Controls	Life-time risk	All SNPs			Removing known locia
				$h_{\mathrm{g}}^2$	s.e.	P value	$h_{\mathrm{g}}^2$	s.e.	P value
High-grade Serous	4098	21,233	0.0055	0.088	0.010	2.2E–16	0.047	0.009	1.83E–09
Clear cell	620	21,233	0.0005	0.067	0.033	0.017	0.046	0.029	0.058
Endometrioid (all)	1342	21,233	0.001	0.032	0.016	0.016	0.020	0.014	0.077
Endometrioid G1/G2	906	21,233	0.001	0.044	0.024	0.025	0.037	0.021	0.037
Endometrioid G3	436	21,233	0.001	0.049	0.046	0.127	0.009	0.041	0.417
Mucinous	658	21,233	0.0005	0.000	0.028	0.5	0.000	0.025	0.5
Unknown	2934	21,233	0.009	0.070	0.015	1.1E–10	0.041	0.012	1.1E–04
All	10,014	21,233	0.009	0.056	0.006	2.2E–16	0.036	0.005	2.2E–16

Results for all iCOGS SNPs, and after removing known associated loci. Disease prevalence of EOC subtypes is calculated as the lifetime risk of ovarian cancer multiplied by the relative proportion of the corresponding EOC subtype. See “Methods” section. Bolded estimates are statistically significantly different from 0

^aLoci removed: WNT4, RSPO1, SYNPO2, GPX6, ABO, ATAD5, C19orf62, CMYC, TIPARP, BNC2, ARHGAP27, TERT, RAD51B/C/D, BRIP1, BARD1, PALB2, NDN, CHMP4C, MLLT10, HNF1B, BRCA1, BRCA2, KRAS, TP53, HER2, AR1D1A and PIK3CA