Table 2.

Genetic correlations and (standard error) between major EOC subtypes as estimated from iCOGS array

Subtype	High-grade serous	Endometrioid (all)	Endometrioid G1/G2	Endometrioid G3	Clear cell	Unknown
High-grade serous	–	0.48 (0.35) P = 0.072	0.24 (0.30) P = 0.21	1.0 (2.66) P = 0.5	0.29 (0.42) P = 0.24	1.0 (0.510) P = 5.1E – 04
Endometrioid (all)	0.63 (0.27) P = 0.0029	–	–	–	0.73 (0.64) P = 0.088	0.50 (0.47) P = 0.12
Endometrioid G1/G2	0.33 (0.23) P = 0.062	–	–	0.36 (1.25) P = 0.30*	0.42 (0.53) P = 0.20	0.37 (0.41) P = 0.18
Endometrioid G3	1.0 (0.83) P = 7.8E–04	–	0.42 (0.56) P = 0.2*	–	1.00 (1.68) P = 0.5	1.0 (4.44) P = 0.5
Clear cell	0.28 (0.33) P = 0.18	0.69 (0.56) P = 0.074	0.52 (0.54) P = 0.14	0.99 (0.87) P = 0.073	–	0.09 (0.55) P = 0.43
Unknown	1.0 (0.30) P = 1.0E–07	0.68 (0.33) P = 0.0082	0.42 (0.29) P = 0.057	1.0 (0.96) P = 0.0049	0.15 (0.39) P = 3.5E–01	–

Lower triangular matrix shows the genetic correlation using all the SNPs in the iCOGS array, while the upper triangular matrix shows the genetic correlation after removing known associated loci. For these calculations, each case was matched to one control in a way that none of the subtypes share any controls. Analyses for mucinous and low-grade serous EOC subtypes were underpowered to yield reliable estimates Bolded estimates are significantly different from 0

^*Significance (P value) where the null hypothesis rG = 1