. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Hum Genet. 2016 Apr 13;135(7):741–756. doi: 10.1007/s00439-016-1663-9

Table 4.

Genetic correlation between risk factors and EOC subtypes using cross-trait LD score regression

	All	HG serous	Endometrioid	Clear cell	Unknown
BMI	0.045 (0.07) P = 0.52	−0.04 (0.08) P = 0.63	0.18 (0.11) P = 0.10	−0.01 (0.16) P = 0.96	0.07 (0.08) P = 0.38
Smoking	−0.34 (0.29) P = 0.23	−0.43 (0.33) P = 0.20	−0.37 (0.43) P = 0.39	−0.44 (0.66) P = 0.51	−0.17 (0.31) P = 0.58
Height	0.081 (0.062) P = 0.19	0.13 (0.09) P = 0.15	0.03 (0.09) P = 0.69	0.24 (0.17) P = 0.17	0.00 (0.08) P = 0.98
Menarche	−0.07 (0.08) P = 0.38	−0.23 (0.13) P = 0.06	−0.04 (0.12) P = 0.75	0.32 (0.36) P = 0.36	0.05 (0.09) P = 0.59
Obesity^* >30 BMI	0.05 (0.09) P = 0.58	−0.02 (0.09) P = 0.86	0.26 (0.17) P = 0.13	−0.18 (0.26) P = 0.50	0.12 (0.11) P = 0.27
Obesity^* >35 BMI	0.019 (0.087) P = 0.83	–0.03 (0.11) P = 0.80	0.02 (0.18) P = 0.90	−0.23 (0.37) P = 0.54	0.17 (0.12) P = 0.17
Obesity^* >40 BMI	−0.02 (0.15) P = 0.88	−0.02 (0.17) P = 0.92	−0.06 (0.30) P = 0.84	NA	0.03 (0.19) P = 0.89
Diabetes	0.04 (0.12) P = 0.75	−0.04 (0.14) P = 0.74	0.04 (0.19) P = 0.84	−0.29 (0.38) P = 0.45	0.21 (0.14) P = 0.15

Estimates and (standard errors) are reported. Analyses for mucinous and low-grade serous EOC subtypes were underpowered to yield reliable estimates

Reference group was individuals with BMI ≤25