Table 5.

Odds Ratios corresponding to 1 standard deviation increase in the PGRS and significance estimates (P values) from the polygenic risk prediction approach between “environmental factors” PGRS and EOC subtypes

	HG serous	Mucinous	Clear cell	Endometrioid	Unknown	ALL
Menarche	0.99 (0.54)	1.09 (0.036)	1.05 (0.2)	1.04 (0.12)	1.04 (0.086)	1.02 (0.17)
BMI	1.04 (0.028)	1.05 (0.26)	1.06 (0.17)	1.07 (0.011)	1.04 (0.068)	1.04 (0.003)
Smoking	1.03 (0.11)	0.93 (0.067)	0.92 (0.049)	1.04 (0.18)	0.95 (0.0071)	0.97 (0.019)
Height	1.03 (0.14)	1.1 (0.015)	1.1 (0.025)	1.04 (0.17)	0.96 (0.06)	1.03 (0.022)
Diabetes	1.04 (0.021)	1.18 (1.1e–05)	1.08 (0.067)	1.07 (0.011)	1.04 (0.034)	1.05 (4.1e–04)
Obesity >30 BMI	1.05 (0.0051)	1.06 (0.15)	1.06 (0.14)	1.04 (0.19)	1.04 (0.032)	1.05 (2.6e–04)
Obesity >35 BMI	1.03 (0.08)	1.05 (0.21)	0.9 (0.012)	1.02 (0.42)	1.05 (0.028)	1.04 (0.0053)
Obesity >40 BMI	1.03 (0.15)	1.06 (0.14)	0.87 (0.0015)	0.96 (0.13)	1.03 (0.19)	0.98 (0.21)

The displayed numbers correspond to the best association p value out of the 11 different PGRS which were derived using different p value thresholds. In this part, we used the total set of controls with each of the EOC subtypes

Bolded estimates are statistically significant (Bonferroni P value threshold 2.9 × 10⁻⁴)

^*Reference group was individuals with BMI ≤25