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. 2016 Aug 8;7:144. doi: 10.3389/fgene.2016.00144

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Copyright © 2016 Sebastiani and Perls.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of the proportion of falsely detected clusters $P W C = (n_{c q}^{^} - 1) / (n_{s} - 1)$ for different significance levels (α = 0.05: left panel; α = 0.01; mid panel; α = 0.001 right panel), vs. the number of variables (top panels) and number of sample profiles generated in 10,000 simulations (bottom panels). The number of sample profiles are presented in quantiles ranges. In each set, data were generated from one cluster, and cluster detection was based on cutting the dendrogram with observed distances D_o using the percentiles of the resampling-based reference distribution D_e.