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. 2016 Aug 8;10:358. doi: 10.3389/fnins.2016.00358

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Copyright © 2016 Baskakov and Katorcha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A diagram illustrating mechanisms that control sialylation of PrP^Sc. (A) The sialylation status of PrP^C is controlled by STs in the trans-Golgi. (B) NEUs do not appear to affect the steady-state sialylation level of PrP^C, presumably because desialylated PrP^C is degraded rapidly. (C) Sialoglycoforms of PrP^C are recruitment into PrP^Sc selectively according to their sialylation status and in a strain-specific manner. (D) In SLOs, PrP^Sc is a subject of post-conversion sialylation by STs. Sias are shown as red diamonds.