Table 2.
The effects of EGF on EGF-mediated protection of tight junctions.
| Cell lines | Inducer | TJ associated proteins | Involved pathways | Reference |
|---|---|---|---|---|
| Caco-2 | Hydrogen peroxide | Increased in tubulin polymerization | PKC-β1 | [50] |
| Caco-2 | Hydrogen peroxide | Increased in tubulin polymerization and decreased in monomeric tubulin | PKC-ξ | [51] |
| Caco-2 | Hydrogen peroxide | Increased F-actin-to-G-actin ratio | PKC-β1 ↑; NF-κB ↓2 | [52] |
| Caco-2 | Acetaldehyde | Occludin ↑; ZO-1 ↑1 | Inhibited tyrosine phosphorylation | [53] |
| Caco-2 | Hydrogen peroxide | F-actin ↑; G-actin ↓ | PLC-γ ↑; NF-κB ↓ | [40] |
| Caco-2 | Hydrogen peroxide | Occludin ↑; ZO-1 ↑ | ERK-MAPK | [23] |
| Caco-2 | Acetaldehyde | Occludin ↑; ZO-1 ↑ | Not mentioned | [54] |
| Caco-2 | Acetaldehyde | Occludin ↑; ZO-1 ↑ | PLC-γ/PKC | [55] |
| Caco-2 | Acetaldehyde | Occludin ↑; ZO-1 ↑ | ERK1/2-MAPK | [24] |
| NRC-1 cells3 | Hydrogen peroxide | ZO-1 ↑; claudin-3 ↑ | PLC-γ/PKC | [56] |
| MCAS4 | None | Claudin-3 ↓ | MEK/ERK or PI3K/Akt |
[57] |
| HUOA5 | Claudin-4 ↓ | |||
| MDCK6 | None | Claudin-4 ↑ | MEK/ERK | [58] |
| MDCK | None | Claudin-2 ↓; claudin-4 ↑ | Src and STAT3 | [25] |
1Symbols ↑ and ↓ indicate increases and decreases in the protein or mRNA expression, respectively. 2Symbols ↑ and ↓ stand for activation and inhibition, respectively. 3Cholangiocytes. 4Mucinous cystadenocarcinoma. 5Serous cystadenocarcinoma. 6Darby canine kidney cells.