Table 1.
OGG1-BER induced expression of genes involved in mast cell degranulation.
| Symbol | Name | GenBank/RefSeq ID | SC (fold) | MC (fold) |
|---|---|---|---|---|
| Itga6 | Integrin alpha 6 | NM_008397 | −1.28 | 29.12 |
| Foxf1 | Forkhead box F1 | NM_010426 | 1.63 | 18.98 |
| Plcg1 | Phospholipase C, gamma 1 | NM_021280 | 1.15 | 17.11 |
| Alb | Albumin | NM_009654 | −1.74 | 15.28 |
| Pla2g3 | Phospholipase A2, group III | NM_172791 | −7.06 | 9.71 |
| Ar | Androgen receptor | NM_013476 | −2.16 | 9.58 |
| Cxcl9 | Chemokine (C-X-C motif) ligand 9 | NM_008599 | −1.51 | 9.09 |
| Ms4a2 | Membrane-spanning 4-domains, subfamily A, member 2 | NM_013516 | 1.33 | 8.38 |
| Tnf | Tumor necrosis factor | NM_013693 | 16.65 | 7.13 |
| Nfkbia | NFKLPa gene enhancer in B cells inhibitor, alpha | NM_010907 | 4.73 | 4.41 |
| Grap2 | GRB2b-related adaptor protein 2 | NM_010815 | 1.18 | 3.53 |
| Itk | Interleukin 2 inducible T cell kinase | NM_010583 | 1.38 | 3.34 |
| Traf6 | Tumor necrosis factor receptor-associated factor 6 | NM_009424 | 1.09 | 2.94 |
| Ccl11 | Chemokine (C-C motif) ligand 11 | NM_011330 | −1.71 | 2.93 |
| Pdpk1 | 3-phosphoinositide dependent protein kinase 1 | NM_011062 | −1.22 | 2.73 |
| Pik3cg | Phosphoinositide-3-kinase, catalytic, gamma polypeptide | NM_020272 | 1.02 | 2.67 |
| Rasgrp1 | RASc guanyl releasing protein 1 | NM_011246 | 1.21 | 2.62 |
| Il1r1 | Interleukin 1 receptor, type I | NM_008362 | 1.24 | 2.55 |
| Pld1 | Phospholipase D1 | NM_008875 | 1.02 | 2.49 |
| Hmox1 | Heme oxygenase 1 | NM_010442 | −1.43 | 2.46 |
| Pik3cb | Phosphatidylinositol 3-kinase, catalytic, beta polypeptide | NM_029094 | −1.02 | 2.34 |
| Fer | Fer (fms/fps related) protein kinase | NM_008000 | −1.60 | 2.33 |
| Ubash3b | Ubiquitin associated and SH3 domain containing, B | NM_176860 | 1.12 | 2.25 |
| Kit | Kit oncogene | NM_021099 | 1.39 | 2.20 |
| Gp1ba | Glycoprotein 1b, alpha polypeptide | NM_010326 | 1.28 | 2.16 |
| Hrh1 | Histamine receptor H1 | NM_008285 | −2.85 | 2.15 |
| Fyn | Fyn proto-oncogene | NM_008054 | 1.21 | 2.14 |
| Plcg2 | Phospholipase C, gamma 2 | NM_172285 | 1.08 | 2.12 |
| Elane | Elastase, neutrophil expressed | NM_015779 | −1.43 | 2.09 |
| Gab2 | Growth factor receptor bound protein 2-associated protein 2 | NM_010248 | 1.15 | 2.09 |
SC, single 8-oxoG challenge; MC, multiple 8-oxoG challenge; NFKLPa, nuclear factor of kappa light polypeptide; GRB2b, growth factor receptor-bound protein 2. RASc, rat sarcoma. The table shows the top ranked genes (MC, 60 min) by expression level (≥2-fold).