Table 2.
OGG1-BER induced expression of genes associated to AHR.
| Symbol | Name | GenBank/RefSeq ID | SC (fold) | MC (fold) |
|---|---|---|---|---|
| Cxcl2 | Chemokine (C-X-C motif) ligand 2 | NM_009140 | 192.95 | 48.55 |
| Bdkrb2 | Bradykinin receptor, beta 2 | NM_009747 | −1.35 | 45.16 |
| Il10 | Interleukin 10 | NM_010548 | 5.84 | 33.51 |
| Tlr9 | Toll-like receptor 9 | NM_031178 | −1.54 | 25.97 |
| Arg1 | Arginase, liver | NM_007482 | −5.00 | 17.71 |
| Cxcl1 | Chemokine (C-X-C motif) ligand 1 | NM_008176 | 54.45 | 15.94 |
| Esr1 | Estrogen receptor 1 (alpha) | NM_007956 | −5.19 | 15.56 |
| Alb | Albumin | NM_009654 | −1.74 | 15.28 |
| Chrm3 | Cholinergic receptor, muscarinic 3, cardiac | NM_033269 | 1.66 | 9.99 |
| Flt1 | Fms-like tyrosine kinase 1 | NM_010228 | −1.13 | 9.06 |
| Chrm2 | Cholinergic receptor, muscarinic 2, cardiac | NM_203491 | −1.79 | 8.73 |
| Vip | Vasoactive intestinal polypeptide | NM_011702 | −2.10 | 7.26 |
| Tnf | Tumor necrosis factor | NM_013693 | 16.65 | 7.13 |
| Col4a3 | Collagen, type IV, alpha 3 | NM_007734 | 1.15 | 6.74 |
| Tac1 | Tachykinin 1 | NM_009311 | −4.28 | 6.70 |
| Mylk3 | Myosin light chain kinase 3 | NM_175441 | −4.08 | 6.35 |
| Ppp1r12a | Protein phosphatase 1, regulatory (inhib) subunit 12A | NM_027892 | −1.08 | 6.06 |
| Ctla4 | Cytotoxic T-lymphocyte-associated protein 4 | NM_009843 | 7.08 | 5.82 |
| Madcam1 | Mucosal vascular addressin cell adhesion molecule 1 | NM_013591 | −1.63 | 5.66 |
| Il1a | Interleukin 1 alpha | NM_010554 | 4.17 | 5.55 |
| Agmat | Agmatine ureohydrolase (agmatinase) | NM_001081408 | −4.28 | 5.03 |
| Il1Rn | Interleukin 1 receptor antagonist | NM_031167 | 1.92 | 4.10 |
| Il2Rb | Interleukin 2 receptor, beta chain | NM_008368 | 1.31 | 4.04 |
| Il9R | Interleukin 9 receptor | NM_008374 | 1.08 | 3.96 |
| Edn1 | Endothelin 1 | NM_010104 | 3.10 | 3.81 |
| Prg2 | Proteoglycan 2, bone marrow | NM_008920 | 2.21 | 3.72 |
| Mme | Membrane metallo-endopeptidase | NM_008604 | −1.07 | 3.66 |
| Ctsg | Cathepsin G | NM_007800 | −1.14 | 3.35 |
| Itk | IL2 inducible T cell kinase | NM_010583 | 1.38 | 3.34 |
| Pik3r1 | PI3Ka, regulatory subunit, polypeptide 1 (p85 alpha) | NM_001024955 | −1.18 | 3.24 |
| Mpo | Myeloperoxidase | NM_010824 | 1.36 | 3.24 |
| Ngfr | Nerve growth factor receptor | NM_033217 | −1.88 | 3.20 |
| Slc7a1 | Solute carrier family 7, member 1 | NM_007513 | −1.28 | 3.19 |
| Pde4d | Phosphodiesterase 4D, cAMP specific | NM_011056 | 1.08 | 3.18 |
| Pde4b | Phosphodiesterase 4B, cAMP specific | NM_019840 | 1.39 | 3.17 |
| Egfr | Epidermal growth factor receptor | NM_007912 | −1.16 | 3.05 |
| Abl1 | C-abl oncogene 1, non-receptor tyrosine kinase | NM_001112703 | 1.11 | 3.01 |
| Etv6 | Ets variant 6 | NM_007961 | −1.05 | 2.98 |
| Tacr2 | Tachykinin receptor 2 | NM_009314 | −1.07 | 2.93 |
| Ccl11 | Chemokine (C-C motif) ligand 11 | NM_011330 | −1.71 | 2.93 |
| Ttf2 | Transcription termination factor, RNA polymerase II | NM_001013026 | 1.06 | 2.92 |
| Il6 | Interleukin 6 | NM_031168 | 10.44 | 2.75 |
| Pde3b | Phosphodiesterase 3B, cGMP-inhibited | NM_011055 | −1.79 | 2.68 |
| Pcdh1 | Protocadherin 1 | NM_029357 | −1.12 | 2.66 |
| Jun | Jun proto-oncogene | NM_010591 | 1.38 | 2.55 |
| Nqo1 | NAD(P)Hb dehydrogenase, quinone 1 | NM_008706 | −2.58 | 2.54 |
| Il1b | Interleukin 1 beta | NM_008361 | 4.15 | 2.52 |
| Cck | Cholecystokinin | NM_031161 | −1.43 | 2.51 |
| F2rl1 | Coagulation factor II (thrombin) receptor-like 1 | NM_007974 | 1.09 | 2.51 |
| Mbp | Myelin basic protein | NM_010777 | −1.40 | 2.48 |
| Itga4 | Integrin alpha 4 | NM_010576 | 1.26 | 2.46 |
| F2r | Coagulation factor II (thrombin) receptor | NM_010169 | 1.46 | 2.39 |
| Selp | Selectin, platelet | NM_011347 | −1.31 | 2.39 |
| Il2ra | Interleukin 2 receptor, alpha chain | NM_008367 | 1.06 | 2.34 |
| Agtr1a | Angiotensin II receptor, type 1a | NM_177322 | 1.72 | 2.33 |
| Fgfr1 | Fibroblast growth factor receptor 1 | NM_010206 | 1.02 | 2.32 |
| Mylk | Myosin, light polypeptide kinase | NM_139300 | 1.24 | 2.30 |
| Klf15 | Kruppel-like factor 15 | NM_023184 | 1.41 | 2.30 |
| Ltb4r2 | Leukotriene B4 receptor 2 | NM_020490 | −7.37 | 2.15 |
| Hrh1 | Histamine receptor H1 | NM_008285 | −2.85 | 2.15 |
| Il5 | Interleukin 5 | NM_010558 | −1.87 | 2.14 |
| Icam1 | Intercellular adhesion molecule 1 | NM_010493 | 1.30 | 2.12 |
| Irak3 | Interleukin-1 receptor-associated kinase 3 | NM_028679 | −1.19 | 2.12 |
| Cftr | Cystic fibrosis transmembrane conductance regulator | NM_021050 | 1.09 | 2.11 |
| Elane | Elastase, neutrophil expressed | NM_015779 | −1.43 | 2.09 |
| Hspd1 | Heat shock protein 1 (chaperonin) | NM_010477 | −2.07 | 2.06 |
SC, single 8-oxoG challenge; MC, multiple 8-oxoG challenge; PI3Ka, phosphatidylinositol 3-kinase; NAD(P)Hb, dihydronicotinamide-adenine dinucleotide phosphate. The table shows the top ranked genes (MC, 60 min) by expression level (≥2-fold).